An improved synthesis of the precursor acetic acid-piperidine-4-yl ester by acetylation of 4-hydroxypiperidine hydrochloride in anhydrous chloroform was developed. A procedure for fast evaluation and characterization of products originated by acetylation of the 4-piperidinol using LC-APCI/MS with an acetonitrile-water gradient method on a Merck Purosphere RP-18 column was also developed. The highly purified precursor allowed the production of [C-11]MP4A for PET studies of acethylcholine neurotransmission system. The tracer was produced with > 98% radiochemical purity, with yields ranging 20-60% (decay-corrected) from EOB. (c) 2005 Elsevier Ltd. All rights reserved.
Citazione: | Carpinelli, A., Magni, F., Cattaneo, A., Matarrese, M., Turolla, E., Todde, S., et al. (2006). Improved synthesis and radiolabeling of [C-11]MP4A, a suitable ligand for the investigation of the cholinergic system using PET. APPLIED RADIATION AND ISOTOPES, 64(2), 182-186. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | No |
Titolo: | Improved synthesis and radiolabeling of [C-11]MP4A, a suitable ligand for the investigation of the cholinergic system using PET |
Autori: | Carpinelli, A; Magni, F; Cattaneo, A; Matarrese, M; Turolla, E; Todde, S; Bosso, N; Kienle, M; Fazio, F |
Autori: | |
Data di pubblicazione: | 2006 |
Lingua: | English |
Rivista: | APPLIED RADIATION AND ISOTOPES |
Digital Object Identifier (DOI): | 10.1016/j.apradiso.2005.07.014 |
Appare nelle tipologie: | 01 - Articolo su rivista |
File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.