A set of new metabolically stable arabinose 5-phosphate analogues possessing phosphate mimetic groups at position 5 was synthesised. Their ability to interact with arabinose 5-phosphate isomerase from Pseudomonas aeruginosa was evaluated by STD-NMR studies. The synthesised compounds were also characterised for their activity in vivo on P. aeruginosa and E. coli strains. Unfortunately, none of the synthesised compounds was able neither to bind API nor to inhibit bacterial growth.

Cipolla, L., Airoldi, C., Sperandeo, P., Gianera, S., Polissi, A., Nicotra, F., et al. (2014). Synthesis and biological evaluation of arabinose 5-phosphate mimics modified at position five. CARBOHYDRATE RESEARCH, 389, 186-191 [10.1016/j.carres.2014.01.004].

Synthesis and biological evaluation of arabinose 5-phosphate mimics modified at position five

CIPOLLA, LAURA FRANCESCA;AIROLDI, CRISTINA;SPERANDEO, PAOLA;GIANERA, SERENA;POLISSI, ALESSANDRA;NICOTRA, FRANCESCO;GABRIELLI, LUCA
2014

Abstract

A set of new metabolically stable arabinose 5-phosphate analogues possessing phosphate mimetic groups at position 5 was synthesised. Their ability to interact with arabinose 5-phosphate isomerase from Pseudomonas aeruginosa was evaluated by STD-NMR studies. The synthesised compounds were also characterised for their activity in vivo on P. aeruginosa and E. coli strains. Unfortunately, none of the synthesised compounds was able neither to bind API nor to inhibit bacterial growth.
Articolo in rivista - Articolo scientifico
Arabinose 5-phosphate, sugar isomerase, NMR interaction studies, phosphate analogues, Pseudomonas aeruginosa
English
186
191
6
Cipolla, L., Airoldi, C., Sperandeo, P., Gianera, S., Polissi, A., Nicotra, F., et al. (2014). Synthesis and biological evaluation of arabinose 5-phosphate mimics modified at position five. CARBOHYDRATE RESEARCH, 389, 186-191 [10.1016/j.carres.2014.01.004].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/50647
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