Collagen matrices have been neoglycosylated with lactose by reductive amination at lysine side chains. AFM analysis highlights that the chemical neoglycosylation does not affect molecular assembly into fibrils. Moreover, ELLA biochemical assays show that the glycan moiety is efficiently exposed on the matrix surface for receptor recognition.

Russo, L., Gautieri, A., Raspanti, M., Taraballi, F., Nicotra, F., Vesentini, S., et al. (2013). Carbohydrate-functionalized collagen matrices: design and characterization of a novel neoglycosylated biomaterial. CARBOHYDRATE RESEARCH, 389(1), 12-17 [10.1016/j.carres.2013.11.008].

Carbohydrate-functionalized collagen matrices: design and characterization of a novel neoglycosylated biomaterial

RUSSO, LAURA;TARABALLI, FRANCESCA;NICOTRA, FRANCESCO;CIPOLLA, LAURA FRANCESCA
2013

Abstract

Collagen matrices have been neoglycosylated with lactose by reductive amination at lysine side chains. AFM analysis highlights that the chemical neoglycosylation does not affect molecular assembly into fibrils. Moreover, ELLA biochemical assays show that the glycan moiety is efficiently exposed on the matrix surface for receptor recognition.
Articolo in rivista - Articolo scientifico
Scientifica
Neoglycosylation, reductive amination, lactose, collagen, AFM, lectins
English
Russo, L., Gautieri, A., Raspanti, M., Taraballi, F., Nicotra, F., Vesentini, S., et al. (2013). Carbohydrate-functionalized collagen matrices: design and characterization of a novel neoglycosylated biomaterial. CARBOHYDRATE RESEARCH, 389(1), 12-17 [10.1016/j.carres.2013.11.008].
Russo, L; Gautieri, A; Raspanti, M; Taraballi, F; Nicotra, F; Vesentini, S; Cipolla, L
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/50642
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