Collagen matrices have been neoglycosylated with lactose by reductive amination at lysine side chains. AFM analysis highlights that the chemical neoglycosylation does not affect molecular assembly into fibrils. Moreover, ELLA biochemical assays show that the glycan moiety is efficiently exposed on the matrix surface for receptor recognition.
Russo, L., Gautieri, A., Raspanti, M., Taraballi, F., Nicotra, F., Vesentini, S., et al. (2013). Carbohydrate-functionalized collagen matrices: design and characterization of a novel neoglycosylated biomaterial. CARBOHYDRATE RESEARCH, 389(1), 12-17 [10.1016/j.carres.2013.11.008].
Carbohydrate-functionalized collagen matrices: design and characterization of a novel neoglycosylated biomaterial
RUSSO, LAURA;TARABALLI, FRANCESCA;NICOTRA, FRANCESCO;CIPOLLA, LAURA FRANCESCA
2013
Abstract
Collagen matrices have been neoglycosylated with lactose by reductive amination at lysine side chains. AFM analysis highlights that the chemical neoglycosylation does not affect molecular assembly into fibrils. Moreover, ELLA biochemical assays show that the glycan moiety is efficiently exposed on the matrix surface for receptor recognition.
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