Results of immunological studies on skin biopsies of 5 patients with Sneddon's syndrome are reported. Also studied were coagulation factors and autoantibodies believed to play a role in this syndrome. Hemostasis was normal except for a mild increase of fibrinogen in one subject; lupus anticoagulant (LAC) and anticardiolipin antibodies were negative in all. The skin biopsies ruled out systemic vasculitis and vasculitis in association with connective tissue diseases. Sneddon's syndrome is a peculiar clinicopathological condition, probably with several etiologies, but is distinct from primary antiphospholipid syndrome.
Fetoni, V., Berti, E., Cecca, E., Carella, F., Sinico, R., Girotti, F. (1994). Sneddon's syndrome: clinical and immunohistochemical findings. CLINICAL NEUROLOGY AND NEUROSURGERY, 96(4), 310-313 [10.1016/0303-8467(94)90120-1].
Sneddon's syndrome: clinical and immunohistochemical findings
BERTI, EMILIO;SINICO, RENATO ALBERTO;
1994
Abstract
Results of immunological studies on skin biopsies of 5 patients with Sneddon's syndrome are reported. Also studied were coagulation factors and autoantibodies believed to play a role in this syndrome. Hemostasis was normal except for a mild increase of fibrinogen in one subject; lupus anticoagulant (LAC) and anticardiolipin antibodies were negative in all. The skin biopsies ruled out systemic vasculitis and vasculitis in association with connective tissue diseases. Sneddon's syndrome is a peculiar clinicopathological condition, probably with several etiologies, but is distinct from primary antiphospholipid syndrome.
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