Primary cutaneous B-cell lymphomas (CBCLs) are indolent lymphoproliferative skin disorders with the only exception of the variant arising on the legs, which is characterized by a more aggressive clinical course. We report a case of CBCL unusual in that it presented with a dermatome-like distribution and showed early peripheral lymph node involvement. The other noteworthy finding is that rearrangement of the bcl-2 gene was detected by polymerase chain reaction in skin tissue samples. The bcl-2 rearrangement, which is usually absent in the classic CBCLs, is likely to play a role in the aggressive clinical behavior of the tumor, although further studies are necessary to confirm it. The hypothesis of a virus causing the dermatomal presentation is intriguing but there is no proof for such speculation at this point.

Marzano, A., Berti, E., Alessi, E. (1999). Primary cutaneous B-cell lymphoma with a dermatomal distribution. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 41(5), 884-886 [10.1016/S0190-9622(99)70352-X].

Primary cutaneous B-cell lymphoma with a dermatomal distribution

Berti, E;
1999

Abstract

Primary cutaneous B-cell lymphomas (CBCLs) are indolent lymphoproliferative skin disorders with the only exception of the variant arising on the legs, which is characterized by a more aggressive clinical course. We report a case of CBCL unusual in that it presented with a dermatome-like distribution and showed early peripheral lymph node involvement. The other noteworthy finding is that rearrangement of the bcl-2 gene was detected by polymerase chain reaction in skin tissue samples. The bcl-2 rearrangement, which is usually absent in the classic CBCLs, is likely to play a role in the aggressive clinical behavior of the tumor, although further studies are necessary to confirm it. The hypothesis of a virus causing the dermatomal presentation is intriguing but there is no proof for such speculation at this point.
Articolo in rivista - Articolo scientifico
Lymphoma, B-Cell; Polymerase Chain Reaction; Genes, bcl-2; Skin; Humans; Gene Rearrangement; Middle Aged; Skin Neoplasms; Lymph Nodes; Female
English
1999
41
5
884
886
none
Marzano, A., Berti, E., Alessi, E. (1999). Primary cutaneous B-cell lymphoma with a dermatomal distribution. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 41(5), 884-886 [10.1016/S0190-9622(99)70352-X].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/49624
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