Aims: This study tested the effects on cardiovascular outcomes of treatments based on nifedipine gastrointestinal therapeutic system (GITS) compared with the diuretic combination co-amilozide in a pre-specified subset of patients with isolated systolic hypertension (ISH) enrolled in the International Nifedipine GITS Study: Intervention as a Goal in Hypertension Treatment (INSIGHT) study. Major findings: Of 6321 randomized patients, 1498 (23.7%) had ISH with a baseline mean BP of 173/88 mmHg in both treatment groups. Mean BP fell by 29/10 mmHg in the nifedipine and 30/10 mmHg in the diuretic group to a mean BP of 144/78 mmHg and 143/79 mmHg, respectively, at endpoint. The percentage of primary outcomes in patients with ISH was not significantly different between the two treatment groups (nifedipine GITS 6.0%, co-amilozide 6.6%). The number of ISH patients with composite secondary outcomes was 90 (12.2%) in the nifedipine GITS group and 110 (14.5%) in the co-amilozide group (not significant). The incidence rates of primary and secondary outcomes were similar in patients without ISH. Conclusion: In patients with ISH, nifedipine GITS and co-amilozide had similar effects on clinical outcomes and BP lowering. They lend support to international guidelines for the treatment of hypertension recommending the use of long-acting dihydropyridine calcium-channel blockers as one treatment option for patients with ISH.
Mancia, G., Ruilope, L.M., Palmer, C.R., Brown, M., Castaigne, A., De Leeuw, P., et al. (2004). Effects of nifedipine GITS and diuretics in isolated systolic hypertension - A subanalysis of the INSIGHT study. BLOOD PRESSURE, 13(5), 310-315.
|Citazione:||Mancia, G., Ruilope, L.M., Palmer, C.R., Brown, M., Castaigne, A., De Leeuw, P., et al. (2004). Effects of nifedipine GITS and diuretics in isolated systolic hypertension - A subanalysis of the INSIGHT study. BLOOD PRESSURE, 13(5), 310-315.|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Titolo:||Effects of nifedipine GITS and diuretics in isolated systolic hypertension - A subanalysis of the INSIGHT study|
|Autori:||Mancia, G; Ruilope, LM; Palmer, CR; Brown, M; Castaigne, A; De Leeuw, P; Rosental, T; Wagener, G|
|Data di pubblicazione:||ott-2004|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1080/08037050410022954|
|Appare nelle tipologie:||01 - Articolo su rivista|