IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishPurpose: The aim was to identify additional noninvasive tools allowing to detect and to quantify the metabolic impairment in patients with mitochondrial myopathies (MM) or McArdle's disease (McA). Methods: Kinetics of adjustment of pulmonary oxygen uptake ((V) over dotO(2) kinetics) during transitions to constant-load moderate-intensity cycle ergometer exercise were determined on 15 MM, 8 McA, 21 patients with signs and/or symptoms of metabolic myopathy but a negative biopsy ("patient controls"; P-CTRL), and 22 healthy untrained controls (CTRL). Results: (V) over dotO(2) kinetics were slower in MM and in McA versus P-CTRL and CTRL, slower in McA versus MM, and not significantly different between P-CTRL and CTRL. The time constants (tau) of the monoexponential function describing the (V) over dotO(2) kinetics were ((X) over bar +/- SE) 59.2 +/- 8.5 s in MM, 87.6 +/- 16.4 s in McA, 36.9 +/- 3.1 s in P-CTRL, and 35.4 +/- 1.9 s in CTRL. In a subgroup of the patients (eight MM and seven McA), tau of (V) over dotO(2) kinetics were negatively correlated with two variables determined in a previous study (Grassi B, Marzorati M, Lanfranconi F, et al. Impaired oxygen extraction in metabolic myopathies: detection and quantification by near-infrared spectroscopy. Muscle Nerve. 2007;35:510-20): a) a muscle oxygenation index, obtained by near-infrared spectroscopy, estimating the peak capacity of skeletal muscle fractional O(2) extraction; and b) (V) over dotO(2) peak. Conclusions: In MM and McA patients, analysis of pulmonary (V) over dotO(2) kinetics during moderate-intensity exercise allows to identify and to quantify, noninvasively, the impairment of skeletal muscle oxidative metabolism. In these patients, the slower (V) over dotO(2) kinetics can be considered a marker of the impaired exercise tolerance. The present data could be useful for clinicians who need an objective, quantitative, and longitudinal evaluation of the impairment to be used in the follow-up of these patients as well as in the assessment of therapeutic interventions
| Citazione: | Grassi, B., Marzorati, M., Lanfranconi, F., Vago, P., Marconi, C., & Morandi, L. (2009). Metabolic myopathies: functional evaluation by analysis of oxygen uptake kinetics. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 41(12), 2120-2127. |
| Tipo: | Articolo in rivista - Articolo scientifico |
| Carattere della pubblicazione: | Scientifica |
| Presenza di un coautore afferente ad Istituzioni straniere: | No |
| Titolo: | Metabolic myopathies: functional evaluation by analysis of oxygen uptake kinetics |
| Autori: | Grassi, B; Marzorati, M; Lanfranconi, F; Vago, P; Marconi, C; Morandi, L |
| Autori: | |
| Data di pubblicazione: | 2009 |
| Lingua: | English |
| Rivista: | MEDICINE AND SCIENCE IN SPORTS AND EXERCISE |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1249/MSS.0b013e3181aae96b |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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