Notch signaling is a crucial determinant of cell fate decision during development and disease in several organs. Notch effects are strictly dependent on the cellular context in which it is activated. In the liver, Notch signaling is involved in biliary tree development and tubulogenesis. Recent advances have shed the light on Notch as a critical player in liver regeneration and repair, as well as in liver metabolism and inflammation and cancer. Notch signaling is finely regulated at several levels. The complexity of the pathway provides several possible targets for development of therapeutic agents able to inhibit Notch. Recent reports have shown that persistent activation of Notch signaling is associated with liver malignancies, particularly hepatocellular with stem cell features and cholangiocarcinoma. These novel findings suggest that interfering with the aberrant activation of Notch pathway may have therapeutic relevance. However, further studies are needed to clarify the mechanisms regulating physiologic and pathologic Notch activation in the adult liver, to better understand the mechanistic role(s) of Notch in liver diseases and to develop safe and specific therapeutic agents

Morell, C., Strazzabosco, M. (2014). Notch signaling and new therapeutic options in liver disease. JOURNAL OF HEPATOLOGY, 60(4), 885-890 [10.1016/j.jhep.2013.11.028].

Notch signaling and new therapeutic options in liver disease

MORELL, CAROLA MARIA;STRAZZABOSCO, MARIO
2014

Abstract

Notch signaling is a crucial determinant of cell fate decision during development and disease in several organs. Notch effects are strictly dependent on the cellular context in which it is activated. In the liver, Notch signaling is involved in biliary tree development and tubulogenesis. Recent advances have shed the light on Notch as a critical player in liver regeneration and repair, as well as in liver metabolism and inflammation and cancer. Notch signaling is finely regulated at several levels. The complexity of the pathway provides several possible targets for development of therapeutic agents able to inhibit Notch. Recent reports have shown that persistent activation of Notch signaling is associated with liver malignancies, particularly hepatocellular with stem cell features and cholangiocarcinoma. These novel findings suggest that interfering with the aberrant activation of Notch pathway may have therapeutic relevance. However, further studies are needed to clarify the mechanisms regulating physiologic and pathologic Notch activation in the adult liver, to better understand the mechanistic role(s) of Notch in liver diseases and to develop safe and specific therapeutic agents
Articolo in rivista - Review Essay
Dll; Mastermind-like 1; Sex determining region Y-box 9; cancer stem cell; cholangiocarcinoma; Hairy enhancer of split-1; Recombination Signal Binding Protein Immunoglobulin Kappa J; hepatocellular carcinoma; mAbs; CSC; hepatic stellate cell; Hairy enhancer of split-related with YRPW motif1; HPC; Sox9; gamma-secretase inhibitor; Alagille syndrome; GSI; monoclonal antibodies; cytokeratin-19; HSC; T-cell acute lymphoblastic leukaemia; Notch intracellular domain; Hes1; Notch inhibitors; Liver cancer; CCA; K7; Notch-1 intracellular domain; CCL4; RBP-Jκ; Hepatocyte nuclear factor 1β; cytokeratin-7; AGS; N2ICD; NICD; HNF1b; MAML1; K19; Jagged-1; Delta-like; N1ICD; T-ALL; carbon tetrachloride; IHBD; Jag-1; Notch-2 intracellular domain; intrahepatic bile duct; Hey1; Notch signaling; Liver repair; hepatic progenitor cell; HCC
English
2014
60
4
885
890
none
Morell, C., Strazzabosco, M. (2014). Notch signaling and new therapeutic options in liver disease. JOURNAL OF HEPATOLOGY, 60(4), 885-890 [10.1016/j.jhep.2013.11.028].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/49368
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