Understanding the inherent complexity of organogenesis and addressing the persistent shortage of organ donors remain paramount scientific challenges. Recent advances in chimeric blastocyst technology offer promising solutions. Two new pioneering studies have successfully generated functional rat-mouse brain chimeras, providing novel insights into brain development and potential regenerative therapies. However, several technical and ethical hurdles persist.
Pluchino, S., Lombardi, I. (2024). Crossing species boundaries in regenerative neuroscience with rat–mouse brain chimeras. LAB ANIMAL, 53(7), 179-180 [10.1038/s41684-024-01394-3].
Crossing species boundaries in regenerative neuroscience with rat–mouse brain chimeras
Lombardi, I
2024
Abstract
Understanding the inherent complexity of organogenesis and addressing the persistent shortage of organ donors remain paramount scientific challenges. Recent advances in chimeric blastocyst technology offer promising solutions. Two new pioneering studies have successfully generated functional rat-mouse brain chimeras, providing novel insights into brain development and potential regenerative therapies. However, several technical and ethical hurdles persist.
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