Objectives: To evaluate whether a relationship exists between season at conception and occurrence of isolated spina bifida (ISB). Study design: All fetuses with prenatal diagnosis of ISB were analyzed according to date of conception. We compared the seasonal rates of conception between ISB fetuses and a control group consisting of a cohort of fetuses delivered during the same period from 1992 to 2009. Results: In the control group, conceptions were equally distributed among the four seasons. Chi-square analysis showed a significantly higher rate of ISB conceptions in the fall compared with the control group (16/36, 44% vs 12467/50533, 25%, Odds Ratio (OR) 2.44, 95% confidence interval 1.21-4.92). Not a single woman with a fetus affected by ISB took preconceptional supplement of folic acid. Conclusions: Seasonality affects the frequency of ISB. We hypothesize that the seasonal differences may reflect dietary and climate changes with reduced intake of folic acid in the fall. © 2013 John Wiley & Sons, Ltd.

Giardini, V., Russo, F., Ornaghi, S., Todyrenchuk, L., & Vergani, P. (2013). Seasonal impact in the frequency of isolated spina bifida. PRENATAL DIAGNOSIS, 30(10), 1007-1009 [10.1002/pd.4175].

Seasonal impact in the frequency of isolated spina bifida

GIARDINI, VALENTINA;RUSSO, FRANCESCA MARIA;ORNAGHI, SARA;VERGANI, PATRIZIA
2013

Abstract

Objectives: To evaluate whether a relationship exists between season at conception and occurrence of isolated spina bifida (ISB). Study design: All fetuses with prenatal diagnosis of ISB were analyzed according to date of conception. We compared the seasonal rates of conception between ISB fetuses and a control group consisting of a cohort of fetuses delivered during the same period from 1992 to 2009. Results: In the control group, conceptions were equally distributed among the four seasons. Chi-square analysis showed a significantly higher rate of ISB conceptions in the fall compared with the control group (16/36, 44% vs 12467/50533, 25%, Odds Ratio (OR) 2.44, 95% confidence interval 1.21-4.92). Not a single woman with a fetus affected by ISB took preconceptional supplement of folic acid. Conclusions: Seasonality affects the frequency of ISB. We hypothesize that the seasonal differences may reflect dietary and climate changes with reduced intake of folic acid in the fall. © 2013 John Wiley & Sons, Ltd.
Articolo in rivista - Articolo scientifico
Scientifica
spina bifida
English
Giardini, V., Russo, F., Ornaghi, S., Todyrenchuk, L., & Vergani, P. (2013). Seasonal impact in the frequency of isolated spina bifida. PRENATAL DIAGNOSIS, 30(10), 1007-1009 [10.1002/pd.4175].
Giardini, V; Russo, F; Ornaghi, S; Todyrenchuk, L; Vergani, P
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/49190
Citazioni
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 5
Social impact