Influencing factors for late-onset preeclampsia

Objective: Different etiologies for early- (<34.0 weeks) and late (34.0 weeks)-onset preeclampsia (EO-LO PE) are reported. The aim of our study is to identify influencing factors for the LO form. Methods: Retrospective study of 284 consecutive women diagnosed as preeclamptic at 22.4-41.5 weeks, from 3/2005 to 10/2011, evaluated in relation to EO versus LO PE. Results: LO PE was identified in 151 cases. Gestational Diabetes Mellitus (11% versus 4%, p=0.04), body mass index (BMI) 35kg/m (9% versus 2%, p=0.03), pathological weight gain for BMI class (30% versus 13%, p=0.001), 5 (58% versus 23%, p<0.001) and 7kg/m BMI increase (19% versus 9%, p=0.04) were more common in LO than in EO PE. At Estimation Regression analysis weighted for Gestational Age (GA) at delivery BMI 35 and 5kg/m BMI increase resulted related to LO PE (OR=3.76, CI(95%)=1.97-17.04; OR=4.28, CI(95%)=2.44-7.54). Conclusions: BMI 35 and 5kg/m increase appeared as influencing factors for LO PE, thus supporting the role of systemic inflammation in its pathogenesis. © 2013 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.