The pH-dependent aggregation of the novel photosensitizer TPCS2a is investigated at low concentration (c=10-6 M) in aqueous media by means of time-correlated single-photon counting, and compared to that of the chemically related photosensitizer TPPS2a. The efficacy of selected solubilizers, i.e., various nonionic Pluronic block copolymers and the nonionic surfactant Tween 80, in inhibiting aggregation of the two photosensitizers is evaluated, which is important for the further formulation of TPCS2a.

Nardo, L., Kristensen, S., Tonnesen, H., Hogset, A., Lilletvedt, M. (2012). Solubilization of the photosensitizers TPCS2a and TPPS2a in aqueous media evaluated by time-resolved fluorescence analysis. PHARMAZIE, 67(7), 598-600 [10.1691/ph.2012.1791].

Solubilization of the photosensitizers TPCS2a and TPPS2a in aqueous media evaluated by time-resolved fluorescence analysis

NARDO, LUCA;
2012

Abstract

The pH-dependent aggregation of the novel photosensitizer TPCS2a is investigated at low concentration (c=10-6 M) in aqueous media by means of time-correlated single-photon counting, and compared to that of the chemically related photosensitizer TPPS2a. The efficacy of selected solubilizers, i.e., various nonionic Pluronic block copolymers and the nonionic surfactant Tween 80, in inhibiting aggregation of the two photosensitizers is evaluated, which is important for the further formulation of TPCS2a.
Articolo in rivista - Articolo scientifico
Porphyrines; photodynamic therapy; aggregation; time-correlated single-photon counting
English
2012
67
7
598
600
none
Nardo, L., Kristensen, S., Tonnesen, H., Hogset, A., Lilletvedt, M. (2012). Solubilization of the photosensitizers TPCS2a and TPPS2a in aqueous media evaluated by time-resolved fluorescence analysis. PHARMAZIE, 67(7), 598-600 [10.1691/ph.2012.1791].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/49108
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