We have developed, optimized, and validated a method for partial volume effect (PVE) correction of oncological lesions in positron emission tomography (PET) clinical studies, based on recovery coefficients (RC) and on PET measurements of lesion-to-background ratio (L/B m) and of lesion metabolic volume. An operator-independent technique, based on an optimised threshold of the maximum lesion uptake, allows to define an isocontour around the lesion on PET images in order to measure both lesion radioactivity uptake and lesion metabolic volume. RC are experimentally derived from PET measurements of hot spheres in hot background, miming oncological lesions. RC were obtained as a function of PET measured sphere-to-background ratio and PET measured sphere metabolic volume, both resulting from the threshold-isocontour technique. PVE correction of lesions of a diameter ranging from 10 mm to 40 mm and for measured L/B m from 2 to 30 was performed using measured RC curves tailored at answering the need to quantify a large variety of real oncological lesions by means of PET. Validation of the PVE correction method resulted to be accurate (>89%) in clinical realistic conditions for lesion diameter > 1 cm, recovering >76% of radioactivity for lesion diameter < 1 cm. Results from patient studies showed that the proposed PVE correction method is suitable and feasible and has an impact on a clinical environment. © 2013 F. Gallivanone et al.
Gallivanone, F., Canevari, C., Gianolli, L., Salvatore, C., Della Rosa, P., Gilardi, M., et al. (2013). A partial volume effect correction tailored for 18F-FDG-PET oncological studies. BIOMED RESEARCH INTERNATIONAL, 2013 [10.1155/2013/780458].
|Citazione:||Gallivanone, F., Canevari, C., Gianolli, L., Salvatore, C., Della Rosa, P., Gilardi, M., et al. (2013). A partial volume effect correction tailored for 18F-FDG-PET oncological studies. BIOMED RESEARCH INTERNATIONAL, 2013 [10.1155/2013/780458].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||No|
|Titolo:||A partial volume effect correction tailored for 18F-FDG-PET oncological studies|
|Autori:||Gallivanone, F; Canevari, C; Gianolli, L; Salvatore, C; Della Rosa, P; Gilardi, M; Castiglioni, I|
|Data di pubblicazione:||2013|
|Rivista:||BIOMED RESEARCH INTERNATIONAL|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1155/2013/780458|
|Appare nelle tipologie:||01 - Articolo su rivista|