The eukaryotic cell cycle comprises a series of events, whose ordering and correct progression depends on the oscillating activity of cyclin-dependent kinases (Cdks), which safeguard timely duplication and segregation of the genome. Cell division is intimately connected to an evolutionarily conserved DNA damage response (DDR), which involves DNA repair pathways that reverse DNA lesions, as well as checkpoint pathways that inhibit cell cycle progression while repair occurs. There is increasing evidence that Cdks are involved in the DDR, in particular in DNA repair by homologous recombination and in activation of the checkpoint response. However, Cdks have to be carefully regulated, because even an excess of their activity can affect genome stability. In this review, we consider the physiological role of Cdks in the DDR

Trovesi, C., Manfrini, N., Falcettoni, M., Longhese, M. (2013). Regulation of the DNA damage response by cyclin-dependent kinases. JOURNAL OF MOLECULAR BIOLOGY, 425, 4756-4766 [10.1016/j.jmb.2013.04.013].

Regulation of the DNA damage response by cyclin-dependent kinases

LONGHESE, MARIA PIA
2013

Abstract

The eukaryotic cell cycle comprises a series of events, whose ordering and correct progression depends on the oscillating activity of cyclin-dependent kinases (Cdks), which safeguard timely duplication and segregation of the genome. Cell division is intimately connected to an evolutionarily conserved DNA damage response (DDR), which involves DNA repair pathways that reverse DNA lesions, as well as checkpoint pathways that inhibit cell cycle progression while repair occurs. There is increasing evidence that Cdks are involved in the DDR, in particular in DNA repair by homologous recombination and in activation of the checkpoint response. However, Cdks have to be carefully regulated, because even an excess of their activity can affect genome stability. In this review, we consider the physiological role of Cdks in the DDR
Articolo in rivista - Review Essay
Cdk1; checkpoint; HR; NHEJ; resection
English
4756
4766
11
Trovesi, C., Manfrini, N., Falcettoni, M., Longhese, M. (2013). Regulation of the DNA damage response by cyclin-dependent kinases. JOURNAL OF MOLECULAR BIOLOGY, 425, 4756-4766 [10.1016/j.jmb.2013.04.013].
Trovesi, C; Manfrini, N; Falcettoni, M; Longhese, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/48665
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