Background Inflammation appears to be important in the pathogenesis of acute myocardial infarction (AMI). Methods and Results Cardiac [18-F]-fluoro-deoxy-glucose (FDG) uptake by positron emission tomography/computed tomography (PET/CT)-scan was investigated in 12 fasting patients with first AMI (FAMI) single-vessel disease after successful primary percutaneous coronary intervention and at 9 weeks follow-up, and in 12 controls. The average FDG uptake (aFDGu) of the 28 left ventricular (LV) wall segments defined on the PET/CT images of the 12 FAMI patients was 1.28±0.57-fold higher than the activity present in the LV cavity. By contrast, the aFDGu of the 12 controls was 0.70±22 (p<0.001). The segmental aFDGu in the FAMI was multifocal in both the culprit and non-culprit segments; it was less than LV cavity activity in 38%, 1-2-fold greater in 51.8% and more than 2-fold greater in 10.2%. At follow-up, aFDGu was significantly increased in both culprit and non-culprit segments (1.69±1.15, p<0.001). Statistically significant differences between FAMI and controls patients were only found for interleukin-6 plasma levels on admission (11.3±7.7 pg/ml vs 2.2±1.3 pg/ml; p<0.004). Conclusion Multifocal, non-infarct related, cardiac-FDG-uptake occurred immediately after AMI and persisted at follow-up. The cause of these striking and consistent findings is still speculative

Godino, C., Messa, M., Gianolli, L., Landoni, C., Margonato, A., Cera, M., et al. (2008). Multifocal, persistent cardiac uptake of [18-F]-Fluoro-Deoxy-Glucose detected by positron emission tomography in patients with acute myocardial infarction. CIRCULATION JOURNAL, 72(11), 1821-1828 [10.1253/circj.CJ-08-0046].

Multifocal, persistent cardiac uptake of [18-F]-Fluoro-Deoxy-Glucose detected by positron emission tomography in patients with acute myocardial infarction

MESSA, MARIA CRISTINA;LANDONI, CLAUDIO;FAZIO, FERRUCCIO;
2008

Abstract

Background Inflammation appears to be important in the pathogenesis of acute myocardial infarction (AMI). Methods and Results Cardiac [18-F]-fluoro-deoxy-glucose (FDG) uptake by positron emission tomography/computed tomography (PET/CT)-scan was investigated in 12 fasting patients with first AMI (FAMI) single-vessel disease after successful primary percutaneous coronary intervention and at 9 weeks follow-up, and in 12 controls. The average FDG uptake (aFDGu) of the 28 left ventricular (LV) wall segments defined on the PET/CT images of the 12 FAMI patients was 1.28±0.57-fold higher than the activity present in the LV cavity. By contrast, the aFDGu of the 12 controls was 0.70±22 (p<0.001). The segmental aFDGu in the FAMI was multifocal in both the culprit and non-culprit segments; it was less than LV cavity activity in 38%, 1-2-fold greater in 51.8% and more than 2-fold greater in 10.2%. At follow-up, aFDGu was significantly increased in both culprit and non-culprit segments (1.69±1.15, p<0.001). Statistically significant differences between FAMI and controls patients were only found for interleukin-6 plasma levels on admission (11.3±7.7 pg/ml vs 2.2±1.3 pg/ml; p<0.004). Conclusion Multifocal, non-infarct related, cardiac-FDG-uptake occurred immediately after AMI and persisted at follow-up. The cause of these striking and consistent findings is still speculative
No
Articolo in rivista - Articolo scientifico
Scientifica
FDG uptake; Inflammation; Myocardial infarction, PET, MI
English
Godino, C., Messa, M., Gianolli, L., Landoni, C., Margonato, A., Cera, M., et al. (2008). Multifocal, persistent cardiac uptake of [18-F]-Fluoro-Deoxy-Glucose detected by positron emission tomography in patients with acute myocardial infarction. CIRCULATION JOURNAL, 72(11), 1821-1828 [10.1253/circj.CJ-08-0046].
Godino, C; Messa, M; Gianolli, L; Landoni, C; Margonato, A; Cera, M; Coli, S; Cianflone, D; Fazio, F; Maseri, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/4833
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