Synthesis and in vitro testing of a prodrug designed for the controlled delivery of the anticancer drug camptothecin within pancreatic cancer cells are reported. Our study reveals a non-conventional pharmacokinetic release characterized by an exponential pattern before reaching the half-life (t1/2) and a linear pattern thereafter. The release mechanism was triggered either by hydrolytic enzymes and/or by the acid microenvironment of cancer cells.
Venturi, S., Chiaradonna, F., Gatti, F., La Ferla, B., Parolini, R., Zerbato, B. (2024). Chiral trimethyl lock based on vicinal disubstituent effect: prolonged release of Camptothecin into cancer cells. CHEMICAL COMMUNICATIONS, 60(51), 6524-6527 [10.1039/d4cc01220h].
Chiral trimethyl lock based on vicinal disubstituent effect: prolonged release of Camptothecin into cancer cells
Chiaradonna, Ferdinando;La Ferla, Barbara
;Parolini, Roberta;Zerbato, Barbara
2024
Abstract
Synthesis and in vitro testing of a prodrug designed for the controlled delivery of the anticancer drug camptothecin within pancreatic cancer cells are reported. Our study reveals a non-conventional pharmacokinetic release characterized by an exponential pattern before reaching the half-life (t1/2) and a linear pattern thereafter. The release mechanism was triggered either by hydrolytic enzymes and/or by the acid microenvironment of cancer cells.
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