Objective: Coated medical devices have been shown to reduce catheter-related infections. We coated endotracheal tubes (ETT) with silver sulfadiazine (SSD), and tested them in a clinical study to assess the feasibility, safety, and efficacy of preventing bacterial colonization. Design: A prospective, randomized clinical trial, phase I-II. Setting: Academic intensive care unit (ICU). Participants: Forty-six adult patients expected to need 12-24 h of intubation were randomized into two groups. Interventions: Patients were randomized to be intubated with a standard non-coated ETT (St-ETT, n = 23; control group), or with a SSD-coated ETT (SSD-ETT, n = 23). Measurements and results: Coating with SSD prevented bacterial colonization of the ETT (frequency of colonization: SSD-ETT 0/23, St-ETT 8/23; p < 0.01). No organized bacterial biofilm could be identified on the lumen of any ETT; however, SSD was associated with a thinner mucus layer (in the SSD-ETT secretion deposits ranged from 0 to 200 μm; in the St-ETT deposits ranged between 50 and 700 μm). No difference was observed between the two groups in the tracheobronchial brush samples (frequency of colonization: SSD-ETT 0/23, St-ETT 2/23; p = 0.48). No adverse reactions were observed with the implementation of the novel device. Conclusion: SSD-ETT can be safely used in preventing bacterial colonization and narrowing of the ETT in patients intubated for up to 24 h (mean intubation time 16 h). © 2008 Springer-Verlag.
Berra, L., Kolobow, T., Laquerriere, P., Pitts, B., Bramati, S., Pohlmann, J., et al. (2008). Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial. INTENSIVE CARE MEDICINE, 34(6), 1030-1037 [10.1007/s00134-008-1100-1].
Citazione: | Berra, L., Kolobow, T., Laquerriere, P., Pitts, B., Bramati, S., Pohlmann, J., et al. (2008). Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial. INTENSIVE CARE MEDICINE, 34(6), 1030-1037 [10.1007/s00134-008-1100-1]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Titolo: | Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial | |
Autori: | Berra, L; Kolobow, T; Laquerriere, P; Pitts, B; Bramati, S; Pohlmann, J; Marelli, C; Panzeri, M; Brambillasca, P; Villa, F; Baccarelli, A; Bouthors, S; Stelfox, HT; Bigatello, LM; Moss, J; Pesenti, A | |
Autori: | ||
Data di pubblicazione: | giu-2008 | |
Lingua: | English | |
Rivista: | INTENSIVE CARE MEDICINE | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00134-008-1100-1 | |
Appare nelle tipologie: | 01 - Articolo su rivista |