IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishObjective: Coated medical devices have been shown to reduce catheter-related infections. We coated endotracheal tubes (ETT) with silver sulfadiazine (SSD), and tested them in a clinical study to assess the feasibility, safety, and efficacy of preventing bacterial colonization. Design: A prospective, randomized clinical trial, phase I-II. Setting: Academic intensive care unit (ICU). Participants: Forty-six adult patients expected to need 12-24 h of intubation were randomized into two groups. Interventions: Patients were randomized to be intubated with a standard non-coated ETT (St-ETT, n = 23; control group), or with a SSD-coated ETT (SSD-ETT, n = 23). Measurements and results: Coating with SSD prevented bacterial colonization of the ETT (frequency of colonization: SSD-ETT 0/23, St-ETT 8/23; p < 0.01). No organized bacterial biofilm could be identified on the lumen of any ETT; however, SSD was associated with a thinner mucus layer (in the SSD-ETT secretion deposits ranged from 0 to 200 μm; in the St-ETT deposits ranged between 50 and 700 μm). No difference was observed between the two groups in the tracheobronchial brush samples (frequency of colonization: SSD-ETT 0/23, St-ETT 2/23; p = 0.48). No adverse reactions were observed with the implementation of the novel device. Conclusion: SSD-ETT can be safely used in preventing bacterial colonization and narrowing of the ETT in patients intubated for up to 24 h (mean intubation time 16 h). © 2008 Springer-Verlag.
http://hdl.handle.net/10281/4814| Citazione: | Berra, L., Kolobow, T., Laquerriere, P., Pitts, B., Bramati, S., Pohlmann, J., et al. (2008). Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial. INTENSIVE CARE MEDICINE, 34(6), 1030-1037. |
| Tipo: | Articolo in rivista - Articolo scientifico |
| Carattere della pubblicazione: | Scientifica |
| Titolo: | Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial |
| Autori: | Berra, L; Kolobow, T; Laquerriere, P; Pitts, B; Bramati, S; Pohlmann, J; Marelli, C; Panzeri, M; Brambillasca, P; Villa, F; Baccarelli, A; Bouthors, S; Stelfox, HT; Bigatello, LM; Moss, J; Pesenti, A |
| Autori interni: | PESENTI, ANTONIO MARIA |
| Data di pubblicazione: | giu-2008 |
| Lingua: | English |
| Rivista: | INTENSIVE CARE MEDICINE |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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