Natural products from mushrooms, plants, microalgae, and cyanobacteria have been intensively explored and studied for their preventive or therapeutic potential. Among age-related pathologies, neurodegenerative diseases (such as Alzheimer's and Parkinson's diseases) represent a worldwide health and social problem. Since several pathological mechanisms are associated with neurodegeneration, promising strategies against neurodegenerative diseases are aimed to target multiple processes. These approaches usually avoid premature cell death and the loss of function of damaged neurons. This review focuses attention on the preventive and therapeutic potential of several compounds derived from natural sources, which could be exploited for their neuroprotective effect. Curcumin, resveratrol, ergothioneine, and phycocyanin are presented as examples of successful approaches, with a special focus on possible strategies to improve their delivery to the brain.

Moukham, H., Lambiase, A., Barone, G., Tripodi, F., Coccetti, P. (2024). Exploiting Natural Niches with Neuroprotective Properties: A Comprehensive Review. NUTRIENTS, 16(9) [10.3390/nu16091298].

Exploiting Natural Niches with Neuroprotective Properties: A Comprehensive Review

Moukham, Hind
Co-primo
;
Lambiase, Alessia
Co-primo
;
Tripodi, Farida
;
Coccetti, Paola
Ultimo
2024

Abstract

Natural products from mushrooms, plants, microalgae, and cyanobacteria have been intensively explored and studied for their preventive or therapeutic potential. Among age-related pathologies, neurodegenerative diseases (such as Alzheimer's and Parkinson's diseases) represent a worldwide health and social problem. Since several pathological mechanisms are associated with neurodegeneration, promising strategies against neurodegenerative diseases are aimed to target multiple processes. These approaches usually avoid premature cell death and the loss of function of damaged neurons. This review focuses attention on the preventive and therapeutic potential of several compounds derived from natural sources, which could be exploited for their neuroprotective effect. Curcumin, resveratrol, ergothioneine, and phycocyanin are presented as examples of successful approaches, with a special focus on possible strategies to improve their delivery to the brain.
Articolo in rivista - Review Essay
Alzheimer’s disease (AD); Parkinson’s disease (PD); curcumin; delivery strategies; ergothioneine; neuroprotection; phycocyanin; resveratrol;
English
26-apr-2024
2024
16
9
1298
open
Moukham, H., Lambiase, A., Barone, G., Tripodi, F., Coccetti, P. (2024). Exploiting Natural Niches with Neuroprotective Properties: A Comprehensive Review. NUTRIENTS, 16(9) [10.3390/nu16091298].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/477920
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