β-glucans are a large class of complex polysaccharides found in abundant sources. Our dietary sources of β-glucans are cereals that include oats and barley, and non-cereal sources can consist of mushrooms, microalgae, bacteria, and seaweeds. There is substantial clinical interest in β-glucans; as they can be used for a variety of diseases including cancer and cardiovascular conditions. Suitable sources of β-glucans for biopharmaceutical applications include bacteria, microalgae, mycelium, and yeast. Environmental factors including culture medium can influence the biomass and ultimately β-glucan content. Therefore, cultivation conditions for the above organisms can be controlled for sustainable enhanced production of β-glucans. This review discusses the various sources of β-glucans and their cultivation conditions that may be optimised to exploit sustainable production. Finally, this article discusses the immune-modulatory potential of β-glucans from these sources.

Murphy, E., Rezoagli, E., Collins, C., Saha, S., Major, I., Murray, P. (2023). Sustainable production and pharmaceutical applications of β-glucan from microbial sources. MICROBIOLOGICAL RESEARCH, 274 [10.1016/j.micres.2023.127424].

Sustainable production and pharmaceutical applications of β-glucan from microbial sources

Rezoagli E.;
2023

Abstract

β-glucans are a large class of complex polysaccharides found in abundant sources. Our dietary sources of β-glucans are cereals that include oats and barley, and non-cereal sources can consist of mushrooms, microalgae, bacteria, and seaweeds. There is substantial clinical interest in β-glucans; as they can be used for a variety of diseases including cancer and cardiovascular conditions. Suitable sources of β-glucans for biopharmaceutical applications include bacteria, microalgae, mycelium, and yeast. Environmental factors including culture medium can influence the biomass and ultimately β-glucan content. Therefore, cultivation conditions for the above organisms can be controlled for sustainable enhanced production of β-glucans. This review discusses the various sources of β-glucans and their cultivation conditions that may be optimised to exploit sustainable production. Finally, this article discusses the immune-modulatory potential of β-glucans from these sources.
Articolo in rivista - Review Essay
Bacteria; Fungi; Immune-modulation; Micro-algae; Yeast; β-glucan;
English
5-giu-2023
2023
274
127424
none
Murphy, E., Rezoagli, E., Collins, C., Saha, S., Major, I., Murray, P. (2023). Sustainable production and pharmaceutical applications of β-glucan from microbial sources. MICROBIOLOGICAL RESEARCH, 274 [10.1016/j.micres.2023.127424].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/476710
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