Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding. Objective: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR). Methods: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry). Results: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12–2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37–4.56], P = 0.003; P-difference with women = 0.029). Conclusions: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.

Domenighetti, C., Sugier, P., Ashok Kumar Sreelatha, A., Schulte, C., Grover, S., Mohamed, O., et al. (2022). Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study. MOVEMENT DISORDERS, 37(4), 857-864 [10.1002/mds.28902].

Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study

Ferrarese C.;
2022

Abstract

Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding. Objective: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR). Methods: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry). Results: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12–2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37–4.56], P = 0.003; P-difference with women = 0.029). Conclusions: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.
Articolo in rivista - Review Essay
dairy intake; Parkinson's disease; Mendelian randomization
English
2022
37
4
857
864
none
Domenighetti, C., Sugier, P., Ashok Kumar Sreelatha, A., Schulte, C., Grover, S., Mohamed, O., et al. (2022). Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study. MOVEMENT DISORDERS, 37(4), 857-864 [10.1002/mds.28902].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/476506
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