The liver has many functions including metabolic homeostasis, disposal of endotoxins and xenotoxins, metabolism of bilirubin and urea, and bile formation and secretion. The process of bile formation depends on the liver synthesis and the canalicular secretion of bile acids. Besides their roles in dietary lipid absorption and cholesterol homeostasis, bile acids also play a key role as signaling molecules in the regulation of hepatic metabolism and energy homeostasis. The regenerative ability of the liver lies in the multiple niches of biliary tree stem cells.
Carbone, M., Strazzabosco, M. (2020). Introduction to the Physiology, Immunology and Pathology of the Liver and Biliary Tree. In J. Neuberger, G.M. Hirschfield (a cura di), Autoimmune Liver Disease: Management and Clinical Practice (pp. 3-20). wiley [10.1002/9781119532637.ch1].
Introduction to the Physiology, Immunology and Pathology of the Liver and Biliary Tree
Carbone M.
;
2020
Abstract
The liver has many functions including metabolic homeostasis, disposal of endotoxins and xenotoxins, metabolism of bilirubin and urea, and bile formation and secretion. The process of bile formation depends on the liver synthesis and the canalicular secretion of bile acids. Besides their roles in dietary lipid absorption and cholesterol homeostasis, bile acids also play a key role as signaling molecules in the regulation of hepatic metabolism and energy homeostasis. The regenerative ability of the liver lies in the multiple niches of biliary tree stem cells.
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