In contact lens (CL) wear, dehydration needs to be tailored to avoid dryness and related symptoms. In this view, this work aims to assess and compare the in-vitro dehydration kinetics of five CL materials, including the newly developed Kalifilcon A CL. At 36 °C and 60% relative humidity, the in-vitro dehydration kinetics of the different CLs were compared using a gravimetric method. CLs were analyzed either after a rinse of a few seconds in preservative-free saline solution or after a 24-h incubation in the same solution. A model based on the Fick diffusion equation was employed to deduce a water kinetics coefficient, providing insights into water diffusion within the polymeric matrix. The study reveals that all materials exhibit a non-Fickian dehydration behavior, with significant differences in dehydration kinetics coefficients and dehydration rate slopes. Etafilcon A and Omafilcon A, both hydrogel CLs, exhibit a similar behavior, different compared to the pattern shown by Senofilcon A and Delefilcon A, silicone-hydrogel CLs. Notably, Kalifilcon A, despite being a silicone-hydrogel, displays a hydration behavior reminiscent of hydrogel CLs.

Ponzini, E., Maspero, F., Galli, A., Tavazzi, S. (2024). In-vitro dehydration kinetics coefficient of Kalifilcon A and other contact lens materials. SCIENTIFIC REPORTS, 14(1) [10.1038/s41598-024-55937-2].

In-vitro dehydration kinetics coefficient of Kalifilcon A and other contact lens materials

Ponzini, E
Primo
;
Maspero, F
Secondo
;
Galli, A
Penultimo
;
Tavazzi, S
Ultimo
2024

Abstract

In contact lens (CL) wear, dehydration needs to be tailored to avoid dryness and related symptoms. In this view, this work aims to assess and compare the in-vitro dehydration kinetics of five CL materials, including the newly developed Kalifilcon A CL. At 36 °C and 60% relative humidity, the in-vitro dehydration kinetics of the different CLs were compared using a gravimetric method. CLs were analyzed either after a rinse of a few seconds in preservative-free saline solution or after a 24-h incubation in the same solution. A model based on the Fick diffusion equation was employed to deduce a water kinetics coefficient, providing insights into water diffusion within the polymeric matrix. The study reveals that all materials exhibit a non-Fickian dehydration behavior, with significant differences in dehydration kinetics coefficients and dehydration rate slopes. Etafilcon A and Omafilcon A, both hydrogel CLs, exhibit a similar behavior, different compared to the pattern shown by Senofilcon A and Delefilcon A, silicone-hydrogel CLs. Notably, Kalifilcon A, despite being a silicone-hydrogel, displays a hydration behavior reminiscent of hydrogel CLs.
Articolo in rivista - Articolo scientifico
Gels and hydrogels, Polymers, Characterization and analytical techniques
English
3-apr-2024
2024
14
1
7870
open
Ponzini, E., Maspero, F., Galli, A., Tavazzi, S. (2024). In-vitro dehydration kinetics coefficient of Kalifilcon A and other contact lens materials. SCIENTIFIC REPORTS, 14(1) [10.1038/s41598-024-55937-2].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/474179
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