Neonatal and infantile cholestasis (NIC) can represent the onset of a surgically correctable disease and of a genetic or metabolic disorder worthy of medical treatment. Timely recognition of NIC and identification of the underlying etiology are paramount to improve outcomes. Upon invitation by the Italian National Institute of Health (ISS), an expert working grouped was formed to formulate evidence-based positions on current knowledge about the diagnosis of NIC. A systematic literature search was conducted to collect evidence about epidemiology, etiology, clinical aspects and accuracy of available diagnostic tests in NIC. Evidence was scored using the GRADE system. All recommendations were approved by a panel of experts upon agreement of at least 75% of the members. The final document was approved by all the panel components. This position document summarizes the collected statements and defines the best-evidence diagnostic approach to cholestasis in the first year of life.

Ranucci, G., Della Corte, C., Alberti, D., Bondioni, M., Boroni, G., Calvo, P., et al. (2022). Diagnostic approach to neonatal and infantile cholestasis: A position paper by the SIGENP liver disease working group. DIGESTIVE AND LIVER DISEASE, 54(1), 40-53 [10.1016/j.dld.2021.09.011].

Diagnostic approach to neonatal and infantile cholestasis: A position paper by the SIGENP liver disease working group

D'Antiga L.;
2022

Abstract

Neonatal and infantile cholestasis (NIC) can represent the onset of a surgically correctable disease and of a genetic or metabolic disorder worthy of medical treatment. Timely recognition of NIC and identification of the underlying etiology are paramount to improve outcomes. Upon invitation by the Italian National Institute of Health (ISS), an expert working grouped was formed to formulate evidence-based positions on current knowledge about the diagnosis of NIC. A systematic literature search was conducted to collect evidence about epidemiology, etiology, clinical aspects and accuracy of available diagnostic tests in NIC. Evidence was scored using the GRADE system. All recommendations were approved by a panel of experts upon agreement of at least 75% of the members. The final document was approved by all the panel components. This position document summarizes the collected statements and defines the best-evidence diagnostic approach to cholestasis in the first year of life.
Articolo in rivista - Articolo scientifico
Alagille syndrome; Biliary atresia; Diagnosis; Genetic liver disease; Inborn errors of metabolism; Jaundice; Monogenic liver disease; Newborn;
English
20-ott-2021
2022
54
1
40
53
none
Ranucci, G., Della Corte, C., Alberti, D., Bondioni, M., Boroni, G., Calvo, P., et al. (2022). Diagnostic approach to neonatal and infantile cholestasis: A position paper by the SIGENP liver disease working group. DIGESTIVE AND LIVER DISEASE, 54(1), 40-53 [10.1016/j.dld.2021.09.011].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/473801
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