The use of co-processed materials for Orally Disintegrating Tablets (ODT) preparation by direct compression is well consolidated. However, the evaluation of their potential for ODT preparation by 3D printing technology remains almost unexplored. The present study aimed to estimate the use of commercially available co-processed excipients, conventionally applied in compression protocols, for the preparation of ODTs with binder jetting-3D printing technology. The latter was selected among the 3D printing techniques because the deposition of multiple powder layers allows for obtaining highly porous and easily disintegrating dosage forms. The influence of some process parameters, including layer thickness, type of waveform and spread speed, on the physical and mechanical properties of the prototypes printed were evaluated. Our results suggested that binder jetting-3D printing technology could benefit from the co-processed excipients for the preparation of solid dosage forms. The process optimization conducted with the experiments reported in this work indicated that additional excipients were needed to improve the physical properties of the resulting ODTs.

Ochoa, E., Morelli, L., Salvioni, L., Giustra, M., De Santes, B., Spena, F., et al. (2024). Co-processed materials testing as excipients to produce Orally Disintegrating Tablets (ODT) using binder jet 3D-printing technology. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 194(January 2024), 85-94 [10.1016/j.ejpb.2023.11.023].

Co-processed materials testing as excipients to produce Orally Disintegrating Tablets (ODT) using binder jet 3D-printing technology

Ochoa, Evelyn
Co-primo
;
Morelli, Lucia
Co-primo
;
Salvioni, Lucia;Giustra, Marco;De Santes, Beatrice;Spena, Francesca;Barbieri, Linda;Garbujo, Stefania;Novati, Brian;Tomaino, Giulia;Prosperi, Davide;Colombo, Miriam
2024

Abstract

The use of co-processed materials for Orally Disintegrating Tablets (ODT) preparation by direct compression is well consolidated. However, the evaluation of their potential for ODT preparation by 3D printing technology remains almost unexplored. The present study aimed to estimate the use of commercially available co-processed excipients, conventionally applied in compression protocols, for the preparation of ODTs with binder jetting-3D printing technology. The latter was selected among the 3D printing techniques because the deposition of multiple powder layers allows for obtaining highly porous and easily disintegrating dosage forms. The influence of some process parameters, including layer thickness, type of waveform and spread speed, on the physical and mechanical properties of the prototypes printed were evaluated. Our results suggested that binder jetting-3D printing technology could benefit from the co-processed excipients for the preparation of solid dosage forms. The process optimization conducted with the experiments reported in this work indicated that additional excipients were needed to improve the physical properties of the resulting ODTs.
Articolo in rivista - Articolo scientifico
3D printing; Binder jetting; Co-processed excipients; Orally disintegrating tablets;
English
2-dic-2023
2024
194
January 2024
85
94
none
Ochoa, E., Morelli, L., Salvioni, L., Giustra, M., De Santes, B., Spena, F., et al. (2024). Co-processed materials testing as excipients to produce Orally Disintegrating Tablets (ODT) using binder jet 3D-printing technology. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 194(January 2024), 85-94 [10.1016/j.ejpb.2023.11.023].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/472378
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