Tourette syndrome (TS) is a complex neurodevelopmental disorder characterized by the presence of tics, frequently accompanied by a variety of neuropsychiatric comorbidities. A subset of patients with TS present with severe and disabling symptoms, requiring prompt therapeutic intervention. Some of these manifestations may result in medical emergencies when severe motor or phonic tics lead to damage of anatomical structures closely related to the tic. Examples include myelopathy or radiculopathy following severe neck (“whiplash”) jerks or a variety of self-inflicted injuries. In addition to self-aggression or, less commonly, allo-aggression, some patients exhibit highly inappropriate behavior, suicidal tendencies, and rage attacks which increase the burden of the disease and are important components of “malignant TS”. This subset of TS is frequently associated with comorbid obsessive-compulsive disorder. Therapeutic measures include intensive behavioral therapy, optimization of oral pharmacotherapy, botulinum toxin injections, and deep brain stimulation.

Baizabal-Carvallo, J., Cavanna, A., Jankovic, J. (2024). Tics emergencies and malignant tourette syndrome: Assessment and management. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 159(April 2024) [10.1016/j.neubiorev.2024.105609].

Tics emergencies and malignant tourette syndrome: Assessment and management

Cavanna, AE;
2024

Abstract

Tourette syndrome (TS) is a complex neurodevelopmental disorder characterized by the presence of tics, frequently accompanied by a variety of neuropsychiatric comorbidities. A subset of patients with TS present with severe and disabling symptoms, requiring prompt therapeutic intervention. Some of these manifestations may result in medical emergencies when severe motor or phonic tics lead to damage of anatomical structures closely related to the tic. Examples include myelopathy or radiculopathy following severe neck (“whiplash”) jerks or a variety of self-inflicted injuries. In addition to self-aggression or, less commonly, allo-aggression, some patients exhibit highly inappropriate behavior, suicidal tendencies, and rage attacks which increase the burden of the disease and are important components of “malignant TS”. This subset of TS is frequently associated with comorbid obsessive-compulsive disorder. Therapeutic measures include intensive behavioral therapy, optimization of oral pharmacotherapy, botulinum toxin injections, and deep brain stimulation.
Articolo in rivista - Articolo scientifico
Emergencies; Obsessive-compulsive disorder; Self-injurious behavior; Tics; Tourette syndrome;
English
4-mar-2024
2024
159
April 2024
105609
reserved
Baizabal-Carvallo, J., Cavanna, A., Jankovic, J. (2024). Tics emergencies and malignant tourette syndrome: Assessment and management. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 159(April 2024) [10.1016/j.neubiorev.2024.105609].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/470638
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