hough neuroimaging, pathology and pathophysiology suggest a subcortical and deep cortical involvement in Frontotemporal Lobar Degeneration (FTLD), no studies have comprehensively assessed the associated gray matter (GM) volume changes. We measured caudate, putamen, thalamus, and amygdala GM volume using probabilistic a-priori regions of interest (ROIs) in 53 early FTLD patients (38 behavioral variant FTD [bvFTD], 9 Semantic Dementia [SD], 6 Progressive Non-Fluent Aphasia [PNFA]), and 25 age-matched healthy controls (HC). ANOVA showed significant (P<0.001) main effect of diagnosis, and significant interactions for diagnosis and region, and diagnosis and hemisphere. Post-hoc comparisons with HC showed bilateral GM atrophy in the caudate, putamen and thalamus, in bvFTD; a left-confined GM reduction in the amygdala in SD; and bilateral GM atrophy in the caudate and thalamus, and left-sided GM reduction in the putamen and amygdala in PNFA. Correlation analyses suggested an association between GM volumes and language, psychomotor speed and behavioral disturbances. This study showed a widespread involvement of subcortical and deep cortical GM in early FTLD with patterns specific for clinical entity.

Garibotto, V., Borroni, B., Agosti, C., Premi, E., Alberici, A., Eickhoff, S., et al. (2011). Subcortical and deep cortical atrophy in Frontotemporal Lobar Degeneration. NEUROBIOLOGY OF AGING, 32(5), 875-884 [10.1016/j.neurobiolaging.2009.05.004].

Subcortical and deep cortical atrophy in Frontotemporal Lobar Degeneration

GARIBOTTO, VALENTINA;BELLELLI, GIUSEPPE;
2011

Abstract

hough neuroimaging, pathology and pathophysiology suggest a subcortical and deep cortical involvement in Frontotemporal Lobar Degeneration (FTLD), no studies have comprehensively assessed the associated gray matter (GM) volume changes. We measured caudate, putamen, thalamus, and amygdala GM volume using probabilistic a-priori regions of interest (ROIs) in 53 early FTLD patients (38 behavioral variant FTD [bvFTD], 9 Semantic Dementia [SD], 6 Progressive Non-Fluent Aphasia [PNFA]), and 25 age-matched healthy controls (HC). ANOVA showed significant (P<0.001) main effect of diagnosis, and significant interactions for diagnosis and region, and diagnosis and hemisphere. Post-hoc comparisons with HC showed bilateral GM atrophy in the caudate, putamen and thalamus, in bvFTD; a left-confined GM reduction in the amygdala in SD; and bilateral GM atrophy in the caudate and thalamus, and left-sided GM reduction in the putamen and amygdala in PNFA. Correlation analyses suggested an association between GM volumes and language, psychomotor speed and behavioral disturbances. This study showed a widespread involvement of subcortical and deep cortical GM in early FTLD with patterns specific for clinical entity.
Articolo in rivista - Articolo scientifico
Frontotemporal Lobar Degeneration; Basal ganglia; Probabilistic atlases; Behavioral variant Frontotemporal Dementia; Semantic Dementia; Progressive Non-Fluent Aphasia
English
2011
32
5
875
884
reserved
Garibotto, V., Borroni, B., Agosti, C., Premi, E., Alberici, A., Eickhoff, S., et al. (2011). Subcortical and deep cortical atrophy in Frontotemporal Lobar Degeneration. NEUROBIOLOGY OF AGING, 32(5), 875-884 [10.1016/j.neurobiolaging.2009.05.004].
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S019745800900164X-main.pdf

Solo gestori archivio

Dimensione 979.51 kB
Formato Adobe PDF
979.51 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/47029
Citazioni
  • Scopus 56
  • ???jsp.display-item.citation.isi??? 55
Social impact