Regenerative medicine is an emerging clinical discipline in which cell-based therapies are used to restore the functions of damaged or defective tissues and organs. Along with the well-established use of cells derived from bone marrow or pancreatic islets, novel approaches of cell therapy have recently emerged that appear particularly promising; that is, those using cell-based vaccines and stem cells. This review focuses on the recent developments of these experimental therapeutic approaches and their drawbacks, with specific focus on dendritic cell vaccines in tumours and mesoangioblasts in muscular dystrophies. The authors discuss how the unique properties of a gaseous messenger, NO, may be exploited to overcome some of the drawbacks of these cell-based approaches in combined therapies based on NO-releasing drugs and cell delivery.

Brunelli, S., Rovere-Querini, P., Sciorati, C., Manfredi, A.A., & Clementi, E. (2007). Nitric oxide: emerging concepts about its use in cell-based therapies. EXPERT OPINION ON INVESTIGATIONAL DRUGS, 16(1), 33-43 [10.1517/13543784.16.1.33].

Nitric oxide: emerging concepts about its use in cell-based therapies

BRUNELLI, SILVIA;
2007

Abstract

Regenerative medicine is an emerging clinical discipline in which cell-based therapies are used to restore the functions of damaged or defective tissues and organs. Along with the well-established use of cells derived from bone marrow or pancreatic islets, novel approaches of cell therapy have recently emerged that appear particularly promising; that is, those using cell-based vaccines and stem cells. This review focuses on the recent developments of these experimental therapeutic approaches and their drawbacks, with specific focus on dendritic cell vaccines in tumours and mesoangioblasts in muscular dystrophies. The authors discuss how the unique properties of a gaseous messenger, NO, may be exploited to overcome some of the drawbacks of these cell-based approaches in combined therapies based on NO-releasing drugs and cell delivery.
Articolo in rivista - Review Essay
cell-based vaccines; cGMP; dendritic cells; lymphocytes; mesoangioblasts; muscular dystrophy; NO-releasing drugs; sphingolipids; stem cells
English
33
43
11
Brunelli, S., Rovere-Querini, P., Sciorati, C., Manfredi, A.A., & Clementi, E. (2007). Nitric oxide: emerging concepts about its use in cell-based therapies. EXPERT OPINION ON INVESTIGATIONAL DRUGS, 16(1), 33-43 [10.1517/13543784.16.1.33].
Brunelli, S; Rovere Querini, P; Sciorati, C; Manfredi, A; Clementi, E
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/4685
Citazioni
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 15
Social impact