Aβ-peptide ligands based on a cis-glycofused benzopyran structure have been fluorescently labeled using coumarine derivatives. Among the synthesized compounds, two conserved their binding ability to β-amyloid peptides, as shown by NMR experiments. Moreover, exploiting its fluorescent property, it was demonstrated that one of such compounds was able to cross an in vitro model of blood–brain barrier (BBB) and to stain Aβ‑deposits.
Airoldi, C., Cardona, F., Sironi, E., Colombo, L., Salmona, M., Cambianica, I., et al. (2013). Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer’s disease. PURE AND APPLIED CHEMISTRY, 85(9), 1813-1823 [10.1351/PAC-CON-12-11-07].
Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer’s disease
AIROLDI, CRISTINA;SIRONI, ERIKA;CAMBIANICA, ILARIA NADIA;ORNAGHI, FRANCESCA;SANCINI, GIULIO ALFREDO;NICOTRA, FRANCESCO;LA FERLA, BARBARA
2013
Abstract
Aβ-peptide ligands based on a cis-glycofused benzopyran structure have been fluorescently labeled using coumarine derivatives. Among the synthesized compounds, two conserved their binding ability to β-amyloid peptides, as shown by NMR experiments. Moreover, exploiting its fluorescent property, it was demonstrated that one of such compounds was able to cross an in vitro model of blood–brain barrier (BBB) and to stain Aβ‑deposits.
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