Regulatory T cells participate in immunologic homeostasis by active suppression of inappropriate immune responses. Regulatory T lymphocytes expressing CD4 and CD25 antigens and naturally present in the peripheral blood were the first to be phenotypically characterized. However, their small number and antigen nonspecific suppression has prompted efforts to identify and dissect antigen-specific regulatory T cells. In this review we discuss how antigen-specific regulatory T cells can be identified, the cellular and molecular mechanisms underlying their induction and activity, and the challenges facing their potential clinical application

Vigouroux, S., Yvon, E., Biagi, E., & Brenner, M. (2004). Antigen-induced regulatory T cells. BLOOD, 104(1), 26-33 [10.1182/blood-2004-01-0182].

Antigen-induced regulatory T cells

BIAGI, ETTORE;
2004-07-01

Abstract

Regulatory T cells participate in immunologic homeostasis by active suppression of inappropriate immune responses. Regulatory T lymphocytes expressing CD4 and CD25 antigens and naturally present in the peripheral blood were the first to be phenotypically characterized. However, their small number and antigen nonspecific suppression has prompted efforts to identify and dissect antigen-specific regulatory T cells. In this review we discuss how antigen-specific regulatory T cells can be identified, the cellular and molecular mechanisms underlying their induction and activity, and the challenges facing their potential clinical application
Recensione in rivista
Lymphocyte Activation; Animals; T-Lymphocytes, Regulatory; Receptors, Immunologic; Humans; Antigens, CD; Cytokines; Antigen-Presenting Cells; Receptors, Cell Surface; Immunophenotyping; Immune Tolerance; T-Lymphocytes
English
Vigouroux, S., Yvon, E., Biagi, E., & Brenner, M. (2004). Antigen-induced regulatory T cells. BLOOD, 104(1), 26-33 [10.1182/blood-2004-01-0182].
Vigouroux, S; Yvon, E; Biagi, E; Brenner, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/46186
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