The aim of the study was to investigate differences in 5-HT(2A) receptor binding between healthy volunteers and patients with major depressive disorder (MDD), either never treated before with antidepressants (drug-naive: DN) or responding to paroxetine treatment (drug-treated: DT). METHODS: Nineteen DN patients with MDD and 15 euthymic DT (paroxetine 4 weeks) patients were compared with a group of 20 healthy controls (C) with positron emission tomography (PET) using [(18)F]fluoroethylspiperone ([(18)F]FESP), a 5-HT(2A) and D(2) receptor antagonist. A "binding index" (BI) of [(18)F]FESP to cortical and basal ganglia regions was calculated as the ratio of the activity in these regions to that of cerebellum. Differences in BI between groups, i.e. C versus DN or DT, were assessed by ANOVA, with or without age as covariate (ANCOVA). RESULTS: A significant reduction in BI ( P=0.003 ANOVA, P=0.001 ANCOVA) was found in DN patients in the frontal, occipital, temporal and cingulate cortices, but not in the striatum. No significant differences emerged between C and DT patients. CONCLUSIONS: The reduction of [(18)F]FESP BI in cortical areas of DN depressed, but not of euthymic DT patients suggests an association between the occurrence of depressive symptoms and impairment of cortical 5-HT(2A) receptors. [(18)F]FESP cortical BI may represent a state marker of depression.
Messa, C., Colombo, C., Moresco, R.M., Gobbo, C., Galli, L., Lucignani, G., et al. (2003). 5-HT(2) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: A PET study. PSYCHOPHARMACOLOGY, 167(1), 72-78.
Citazione: | Messa, C., Colombo, C., Moresco, R.M., Gobbo, C., Galli, L., Lucignani, G., et al. (2003). 5-HT(2) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: A PET study. PSYCHOPHARMACOLOGY, 167(1), 72-78. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | No |
Titolo: | 5-HT(2) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: A PET study |
Autori: | Messa, C; Colombo, C; Moresco, RM; Gobbo, C; Galli, L; Lucignani, G; Gilardi, MC; Rizzo, G; Smeraldi, E; Zanardi, R; Artigas, F; Fazio, F |
Autori: | |
Data di pubblicazione: | 2003 |
Lingua: | English |
Rivista: | PSYCHOPHARMACOLOGY |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00213-002-1379-5 |
Appare nelle tipologie: | 01 - Articolo su rivista |