IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishThe aim of the study was to investigate differences in 5-HT(2A) receptor binding between healthy volunteers and patients with major depressive disorder (MDD), either never treated before with antidepressants (drug-naive: DN) or responding to paroxetine treatment (drug-treated: DT). METHODS: Nineteen DN patients with MDD and 15 euthymic DT (paroxetine 4 weeks) patients were compared with a group of 20 healthy controls (C) with positron emission tomography (PET) using [(18)F]fluoroethylspiperone ([(18)F]FESP), a 5-HT(2A) and D(2) receptor antagonist. A "binding index" (BI) of [(18)F]FESP to cortical and basal ganglia regions was calculated as the ratio of the activity in these regions to that of cerebellum. Differences in BI between groups, i.e. C versus DN or DT, were assessed by ANOVA, with or without age as covariate (ANCOVA). RESULTS: A significant reduction in BI ( P=0.003 ANOVA, P=0.001 ANCOVA) was found in DN patients in the frontal, occipital, temporal and cingulate cortices, but not in the striatum. No significant differences emerged between C and DT patients. CONCLUSIONS: The reduction of [(18)F]FESP BI in cortical areas of DN depressed, but not of euthymic DT patients suggests an association between the occurrence of depressive symptoms and impairment of cortical 5-HT(2A) receptors. [(18)F]FESP cortical BI may represent a state marker of depression.
Messa, C., Colombo, C., Moresco, R.M., Gobbo, C., Galli, L., Lucignani, G., et al. (2003). 5-HT(2) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: A PET study. PSYCHOPHARMACOLOGY, 167(1), 72-78 [10.1007/s00213-002-1379-5].
| Citazione: | Messa, C., Colombo, C., Moresco, R.M., Gobbo, C., Galli, L., Lucignani, G., et al. (2003). 5-HT(2) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: A PET study. PSYCHOPHARMACOLOGY, 167(1), 72-78 [10.1007/s00213-002-1379-5]. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | No | |
| Titolo: | 5-HT(2) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: A PET study | |
| Autori: | Messa, C; Colombo, C; Moresco, RM; Gobbo, C; Galli, L; Lucignani, G; Gilardi, MC; Rizzo, G; Smeraldi, E; Zanardi, R; Artigas, F; Fazio, F | |
| Autori: | ||
| Data di pubblicazione: | 2003 | |
| Lingua: | English | |
| Rivista: | PSYCHOPHARMACOLOGY | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00213-002-1379-5 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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