PURPOSE: We compared [11C]choline-positron emission tomography (PET) with [18F]fluorodeoxyglucose-PET for re-staging prostate cancer in a group of 100 patients. MATERIALS AND METHODS: A total of 100 consecutive patients referred for whole body [18F]fluorodeoxyglucose-PET for clinical prostate re-staging after radical treatment for prostate cancer were retrospectively included in the study. Mean prostate specific antigen (PSA) was 6.57 ng./ml. In all cases [11C]choline-PET was also performed. PET studies were done with a multiring device 5 minutes after intravenous injection of approximately 370 MBq. [11C]choline and 60 minutes after injection of approximately 370 MBq. [18F]fluorodeoxyglucose. PET findings were compared with those obtained with different conventional imaging and with PSA assessed at the time of PET and 1 year later. RESULTS: Areas of abnormal focal increases were noted in 47% of patients on [11C]choline-PET and in 27% on [18F]fluorodeoxyglucose-PET. Of the 100 patients 49 had positive conventional imaging findings. All except 14 [11C]choline-PET findings were concordant with conventional imaging, including 6 negative and 8 positive conventional imaging results. All except 1 [11C]choline-PET negative cases also had negative conventional imaging after 1 year. PSA at 1 year remained stable or decreased in 80% and 62% of [11C]choline-PET negative and positive cases, respectively. CONCLUSIONS: [11C]choline-PET seems to be useful for re-staging prostatectomy cases with increasing serum PSA levels. It is superior to [18F]fluorodeoxyglucose-PET and complementary to conventional imaging but with the advantage of staging disease at a single step.
Picchio, M., Messa, C., Landoni, C., Gianolli, L., Sironi, S., Brioschi, M., et al. (2003). Value of [11C]choline PET in re-staging prostate cancer: A comparison with [18F]FDG-PET. THE JOURNAL OF UROLOGY, 169(4), 1337-1340.
|Citazione:||Picchio, M., Messa, C., Landoni, C., Gianolli, L., Sironi, S., Brioschi, M., et al. (2003). Value of [11C]choline PET in re-staging prostate cancer: A comparison with [18F]FDG-PET. THE JOURNAL OF UROLOGY, 169(4), 1337-1340.|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||No|
|Titolo:||Value of [11C]choline PET in re-staging prostate cancer: A comparison with [18F]FDG-PET|
|Autori:||Picchio, M; Messa, C; Landoni, C; Gianolli, L; Sironi, S; Brioschi, M; Matarrese, M; Matei, DV; De Cobelli, F; Del Maschio, A; Rocco, F; Rigatti, P; Fazio, F|
|Data di pubblicazione:||2003|
|Rivista:||THE JOURNAL OF UROLOGY|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/01.ju.0000056901.95996.43|
|Appare nelle tipologie:||01 - Articolo su rivista|