Parkinson's disease (PD) is associated with slowness, especially of sequential movements, and is pathologically characterised by degeneration of dopaminergic neurons, particularly targeting nigro-striatal projections. In turn, nigrostriatal dopamine has been suggested to be critical for the execution of sequential movements. The objective of this study was to investigate in vivo with [11C]raclopride PET changes in regional brain levels of dopamine in healthy volunteers and PD patients during the execution of paced, stereotyped sequential finger movements. Striatal [11C]raclopride binding reflects dopamine D2 receptor availability and is influenced by synaptic levels of endogenous dopamine. During execution of a prelearned sequence of finger movements a significant reduction in binding potential (BP) of [11C]raclopride was seen in both caudate and putamen in healthy volunteers compared to a resting baseline, consistent with release of endogenous dopamine. PD patients also showed attenuated [11C]raclopride BP reductions during the same motor paradigm in striatal areas less affected by the disease process. These findings confirm that striatal dopamine release is a component of movement sequencing and show that dopamine release can be detected in early Parkinson's disease during a behavioural manipulation.
Goerendt, K., Messa, C., Lawrence, A.D., Grasby, P.M., Piccini, P., & Brooks, D.J. (2003). Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study. BRAIN, 126(2), 312-325.
|Citazione:||Goerendt, K., Messa, C., Lawrence, A.D., Grasby, P.M., Piccini, P., & Brooks, D.J. (2003). Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study. BRAIN, 126(2), 312-325.|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||Si|
|Titolo:||Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study|
|Autori:||Goerendt, K; Messa, C; Lawrence, AD; Grasby, PM; Piccini, P; Brooks, DJ|
|Data di pubblicazione:||2003|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1093/brain/awg035|
|Appare nelle tipologie:||01 - Articolo su rivista|