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IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishParkinson's disease (PD) is associated with slowness, especially of sequential movements, and is pathologically characterised by degeneration of dopaminergic neurons, particularly targeting nigro-striatal projections. In turn, nigrostriatal dopamine has been suggested to be critical for the execution of sequential movements. The objective of this study was to investigate in vivo with [11C]raclopride PET changes in regional brain levels of dopamine in healthy volunteers and PD patients during the execution of paced, stereotyped sequential finger movements. Striatal [11C]raclopride binding reflects dopamine D2 receptor availability and is influenced by synaptic levels of endogenous dopamine. During execution of a prelearned sequence of finger movements a significant reduction in binding potential (BP) of [11C]raclopride was seen in both caudate and putamen in healthy volunteers compared to a resting baseline, consistent with release of endogenous dopamine. PD patients also showed attenuated [11C]raclopride BP reductions during the same motor paradigm in striatal areas less affected by the disease process. These findings confirm that striatal dopamine release is a component of movement sequencing and show that dopamine release can be detected in early Parkinson's disease during a behavioural manipulation.
Goerendt, K., Messa, C., Lawrence, A.D., Grasby, P.M., Piccini, P., & Brooks, D.J. (2003). Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study. BRAIN, 126(2), 312-325.
| Citazione: | Goerendt, K., Messa, C., Lawrence, A.D., Grasby, P.M., Piccini, P., & Brooks, D.J. (2003). Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study. BRAIN, 126(2), 312-325. |
| Tipo: | Articolo in rivista - Articolo scientifico |
| Carattere della pubblicazione: | Scientifica |
| Presenza di un coautore afferente ad Istituzioni straniere: | Si |
| Titolo: | Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study |
| Autori: | Goerendt, K; Messa, C; Lawrence, AD; Grasby, PM; Piccini, P; Brooks, DJ |
| Autori: | |
| Data di pubblicazione: | 2003 |
| Lingua: | English |
| Rivista: | BRAIN |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1093/brain/awg035 |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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