Parkinson's disease (PD) is associated with slowness, especially of sequential movements, and is pathologically characterised by degeneration of dopaminergic neurons, particularly targeting nigro-striatal projections. In turn, nigrostriatal dopamine has been suggested to be critical for the execution of sequential movements. The objective of this study was to investigate in vivo with [11C]raclopride PET changes in regional brain levels of dopamine in healthy volunteers and PD patients during the execution of paced, stereotyped sequential finger movements. Striatal [11C]raclopride binding reflects dopamine D2 receptor availability and is influenced by synaptic levels of endogenous dopamine. During execution of a prelearned sequence of finger movements a significant reduction in binding potential (BP) of [11C]raclopride was seen in both caudate and putamen in healthy volunteers compared to a resting baseline, consistent with release of endogenous dopamine. PD patients also showed attenuated [11C]raclopride BP reductions during the same motor paradigm in striatal areas less affected by the disease process. These findings confirm that striatal dopamine release is a component of movement sequencing and show that dopamine release can be detected in early Parkinson's disease during a behavioural manipulation.
Goerendt, K., Messa, C., Lawrence, A.D., Grasby, P.M., Piccini, P., & Brooks, D.J. (2003). Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study. BRAIN, 126(2), 312-325 [10.1093/brain/awg035].
Citazione: | Goerendt, K., Messa, C., Lawrence, A.D., Grasby, P.M., Piccini, P., & Brooks, D.J. (2003). Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study. BRAIN, 126(2), 312-325 [10.1093/brain/awg035]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | Si | |
Titolo: | Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study | |
Autori: | Goerendt, K; Messa, C; Lawrence, AD; Grasby, PM; Piccini, P; Brooks, DJ | |
Autori: | ||
Data di pubblicazione: | 2003 | |
Lingua: | English | |
Rivista: | BRAIN | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1093/brain/awg035 | |
Appare nelle tipologie: | 01 - Articolo su rivista |