Parkinson's disease (PD) is associated with slowness, especially of sequential movements, and is pathologically characterised by degeneration of dopaminergic neurons, particularly targeting nigro-striatal projections. In turn, nigrostriatal dopamine has been suggested to be critical for the execution of sequential movements. The objective of this study was to investigate in vivo with [11C]raclopride PET changes in regional brain levels of dopamine in healthy volunteers and PD patients during the execution of paced, stereotyped sequential finger movements. Striatal [11C]raclopride binding reflects dopamine D2 receptor availability and is influenced by synaptic levels of endogenous dopamine. During execution of a prelearned sequence of finger movements a significant reduction in binding potential (BP) of [11C]raclopride was seen in both caudate and putamen in healthy volunteers compared to a resting baseline, consistent with release of endogenous dopamine. PD patients also showed attenuated [11C]raclopride BP reductions during the same motor paradigm in striatal areas less affected by the disease process. These findings confirm that striatal dopamine release is a component of movement sequencing and show that dopamine release can be detected in early Parkinson's disease during a behavioural manipulation.

Goerendt, K., Messa, M., Lawrence, A., Grasby, P., Piccini, P., & Brooks, D. (2003). Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study. BRAIN, 126(2), 312-325 [10.1093/brain/awg035].

Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study

MESSA, MARIA CRISTINA;
2003

Abstract

Parkinson's disease (PD) is associated with slowness, especially of sequential movements, and is pathologically characterised by degeneration of dopaminergic neurons, particularly targeting nigro-striatal projections. In turn, nigrostriatal dopamine has been suggested to be critical for the execution of sequential movements. The objective of this study was to investigate in vivo with [11C]raclopride PET changes in regional brain levels of dopamine in healthy volunteers and PD patients during the execution of paced, stereotyped sequential finger movements. Striatal [11C]raclopride binding reflects dopamine D2 receptor availability and is influenced by synaptic levels of endogenous dopamine. During execution of a prelearned sequence of finger movements a significant reduction in binding potential (BP) of [11C]raclopride was seen in both caudate and putamen in healthy volunteers compared to a resting baseline, consistent with release of endogenous dopamine. PD patients also showed attenuated [11C]raclopride BP reductions during the same motor paradigm in striatal areas less affected by the disease process. These findings confirm that striatal dopamine release is a component of movement sequencing and show that dopamine release can be detected in early Parkinson's disease during a behavioural manipulation.
Si
Articolo in rivista - Articolo scientifico
Scientifica
Parkinson's disease; dopamine; [11C]raclopride PET; sequential movement
English
312
325
14
Goerendt, K., Messa, M., Lawrence, A., Grasby, P., Piccini, P., & Brooks, D. (2003). Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study. BRAIN, 126(2), 312-325 [10.1093/brain/awg035].
Goerendt, K; Messa, M; Lawrence, A; Grasby, P; Piccini, P; Brooks, D
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/4587
Citazioni
  • Scopus 92
  • ???jsp.display-item.citation.isi??? 79
Social impact