Bone defects pose a heavy burden on patients, orthopedic surgeons, and public health resources. Various pathological conditions cause bone defects including trauma, tumors, inflammation, osteoporosis, and so forth. Auto- and allograft transplantation have been developed as the most commonly used clinic treatment methods, among which autologous bone grafts are the golden standard. Yet the repair of bone defects, especially large-volume defects in the geriatric population or those complicated with systemic disease, is still a challenge for regenerative medicine from the clinical perspective. The fast development of biomaterials and nanomedicine favors the emergence and promotion of efficient bone regeneration therapies. In this review, we briefly summarize the progress of novel biomaterial and nanomedical approaches to bone regeneration and then discuss the current challenges that still hinder their clinical applications in treating bone defects.

Zhou, J., Zhang, Z., Joseph, J., Zhang, X., Ferdows, B., Patel, D., et al. (2021). Biomaterials and nanomedicine for bone regeneration: Progress and future prospects. EXPLORATION, 1(2) [10.1002/EXP.20210011].

Biomaterials and nanomedicine for bone regeneration: Progress and future prospects

Corbo C.
;
2021

Abstract

Bone defects pose a heavy burden on patients, orthopedic surgeons, and public health resources. Various pathological conditions cause bone defects including trauma, tumors, inflammation, osteoporosis, and so forth. Auto- and allograft transplantation have been developed as the most commonly used clinic treatment methods, among which autologous bone grafts are the golden standard. Yet the repair of bone defects, especially large-volume defects in the geriatric population or those complicated with systemic disease, is still a challenge for regenerative medicine from the clinical perspective. The fast development of biomaterials and nanomedicine favors the emergence and promotion of efficient bone regeneration therapies. In this review, we briefly summarize the progress of novel biomaterial and nanomedical approaches to bone regeneration and then discuss the current challenges that still hinder their clinical applications in treating bone defects.
Articolo in rivista - Articolo scientifico
biomaterials; bone defects; nanomedicine; scaffolds; tissue engineering;
English
2021
1
2
20210011
none
Zhou, J., Zhang, Z., Joseph, J., Zhang, X., Ferdows, B., Patel, D., et al. (2021). Biomaterials and nanomedicine for bone regeneration: Progress and future prospects. EXPLORATION, 1(2) [10.1002/EXP.20210011].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/456721
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