In 2000 Baddeley proposed the existence of a new component of working memory, the episodic buffer, which should contribute to the on-line maintenance of integrated memory traces. The author assumed that this component should be critical for immediate recall of a short story that exceeds the capacity of the phonological store. Accordingly, patients with Alzheimer's dementia (AD) should suffer of a deficit of the episodic buffer when immediate recall of a short story is impossible. On the other hand, the episodic buffer should be somewhat preserved in such patients when some IR can occur (Baddeley and Wilson, 2002). We adopted this logic for a voxel-based morphometry study. We compared the distribution of grey-matter density of two such groups of AD patients with and of a group of age-matched controls. We found that both AD groups had a significant atrophy of the left mid-hippocampus; on the other hand, the anterior part of the hippocampus was significantly more atrophic in patients who were also impaired on the immediate prose recall task. Six out of ten patients with no immediate recall were spared at "central executive" tasks. Taken together our findings suggest that the left anterior hippocampus contributes to the episodic buffer of the revised working memory model. We also suggest that the episodic buffer is somewhat independent from the central executive component of working memory.
|Citazione:||Berlingeri, M., Bottini, G., Basilico, S., Silani, G., Zanardi, G., Sberna, M., et al. (2008). Anatomy of the episodic buffer: a voxel-based morphometry study in patients with dementia. BEHAVIOURAL NEUROLOGY, 19(1-2), 29-34.|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Titolo:||Anatomy of the episodic buffer: a voxel-based morphometry study in patients with dementia|
|Autori:||Berlingeri, M; Bottini, G; Basilico, S; Silani, G; Zanardi, G; Sberna, M; Colombo, N; Sterzi, R; Scialfa, G; Paulesu, E.|
|Data di pubblicazione:||2008|
|Appare nelle tipologie:||01 - Articolo su rivista|