The prognosis of cholangiocarcinoma remains poor in spite of the advances in immunotherapy and molecular profiling, which has led to the identification of several targetable genetic alterations. Surgical procedures, including both liver resection and liver transplantation, still represent the treatment with the best curative potential, though the outcomes are significantly compromised by the early development of lymph node metastases. Progression of lymphatic metastasis from the primary tumor to tumor-draining lymph nodes is mediated by tumor-associated lymphangiogenesis, a topic largely overlooked until recently. Recent findings highlight tumor-associated lymphangiogenesis as paradigmatic of the role played by the tumor microenvironment in sustaining cholangiocarcinoma invasiveness and progression. This study reviews the current knowledge about the intercellular signaling and molecular mechanism of tumor-associated lymphangiogenesis in cholangiocarcinoma in the hope of identifying novel therapeutic targets to halt a process that often limits the success of the few available treatments.

Cadamuro, M., Romanzi, A., Guido, M., Sarcognato, S., Cillo, U., Gringeri, E., et al. (2022). Translational Value of Tumor-Associated Lymphangiogenesis in Cholangiocarcinoma. JOURNAL OF PERSONALIZED MEDICINE, 12(7) [10.3390/jpm12071086].

Translational Value of Tumor-Associated Lymphangiogenesis in Cholangiocarcinoma

Cadamuro M.;
2022

Abstract

The prognosis of cholangiocarcinoma remains poor in spite of the advances in immunotherapy and molecular profiling, which has led to the identification of several targetable genetic alterations. Surgical procedures, including both liver resection and liver transplantation, still represent the treatment with the best curative potential, though the outcomes are significantly compromised by the early development of lymph node metastases. Progression of lymphatic metastasis from the primary tumor to tumor-draining lymph nodes is mediated by tumor-associated lymphangiogenesis, a topic largely overlooked until recently. Recent findings highlight tumor-associated lymphangiogenesis as paradigmatic of the role played by the tumor microenvironment in sustaining cholangiocarcinoma invasiveness and progression. This study reviews the current knowledge about the intercellular signaling and molecular mechanism of tumor-associated lymphangiogenesis in cholangiocarcinoma in the hope of identifying novel therapeutic targets to halt a process that often limits the success of the few available treatments.
Articolo in rivista - Review Essay
biliary neoplasia; cancer-associated fibroblasts; lymphatic vessel; tumor microenvironment; VEGF-C; VEGFR-3;
English
30-giu-2022
2022
12
7
1086
open
Cadamuro, M., Romanzi, A., Guido, M., Sarcognato, S., Cillo, U., Gringeri, E., et al. (2022). Translational Value of Tumor-Associated Lymphangiogenesis in Cholangiocarcinoma. JOURNAL OF PERSONALIZED MEDICINE, 12(7) [10.3390/jpm12071086].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/449125
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