Autoimmune cholestatic liver diseases are rare hepato-biliary disorders characterized by a progressive, inflammatory destruction of bile ducts. Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are the main autoimmune cholestatic liver diseases. Both may evolve into secondary biliary cirrhosis and its complications.Therapeutic options are limited and liver transplantation remains the only definitive treatment for PBC and PSC. Most PBC and PSC patients have a typical presentation, which does not require liver biopsy. However, in routine clinical practice, important variants or specific subgroups that benefit from liver biopsy for proper management may be observed. Herein, we provide a general overview of clinical and pathological characteristic of PBC and PSC, highlighting the most important features for routine diagnostic practice.

Sarcognato, S., Sacchi, D., Grillo, F., Cazzagon, N., Fabris, L., Cadamuro, M., et al. (2021). Autoimmune biliary diseases: Primary biliary cholangitis and primary sclerosing cholangitis. PATHOLOGICA, 113(3), 170-184 [10.32074/1591-951X-245].

Autoimmune biliary diseases: Primary biliary cholangitis and primary sclerosing cholangitis

Cadamuro M.;
2021

Abstract

Autoimmune cholestatic liver diseases are rare hepato-biliary disorders characterized by a progressive, inflammatory destruction of bile ducts. Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are the main autoimmune cholestatic liver diseases. Both may evolve into secondary biliary cirrhosis and its complications.Therapeutic options are limited and liver transplantation remains the only definitive treatment for PBC and PSC. Most PBC and PSC patients have a typical presentation, which does not require liver biopsy. However, in routine clinical practice, important variants or specific subgroups that benefit from liver biopsy for proper management may be observed. Herein, we provide a general overview of clinical and pathological characteristic of PBC and PSC, highlighting the most important features for routine diagnostic practice.
Articolo in rivista - Review Essay
Autoimmune cholangitis; Immune-mediated cholangitis; Overlap variants; PBC; PSC;
English
2021
113
3
170
184
open
Sarcognato, S., Sacchi, D., Grillo, F., Cazzagon, N., Fabris, L., Cadamuro, M., et al. (2021). Autoimmune biliary diseases: Primary biliary cholangitis and primary sclerosing cholangitis. PATHOLOGICA, 113(3), 170-184 [10.32074/1591-951X-245].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/449118
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