Organization of the actin cytoskeleton, the cytosolic free-calcium concentrations and ATP levels were analyzed in 3T3 mouse fibroblasts treated with 0.75 or 1.5 mM MPTP. In the presence of the drug actin filaments were time- and dose-dependently presently disorganized, ATP level was unaffected and intracellular calcium increased within 5 s. The correlation between MPTP cytotoxicity and [Ca2+]i level emerging from these results, suggests that the primary effect of the molecule itself is on the plasma membrane's integrity for calcium ion regulation. © 1994.

Urani, C., Brambilla, E., Santagostino, A., & Camatini, M. (1994). 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) affects the actin cytoskeleton and calcium level of Swiss 3T3 mouse fibroblasts. TOXICOLOGY, 91(2), 117-126 [10.1016/0300-483X(94)02791-9].

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) affects the actin cytoskeleton and calcium level of Swiss 3T3 mouse fibroblasts

URANI, CHIARA;SANTAGOSTINO, ANGELA;CAMATINI, MARINA CARLA
1994

Abstract

Organization of the actin cytoskeleton, the cytosolic free-calcium concentrations and ATP levels were analyzed in 3T3 mouse fibroblasts treated with 0.75 or 1.5 mM MPTP. In the presence of the drug actin filaments were time- and dose-dependently presently disorganized, ATP level was unaffected and intracellular calcium increased within 5 s. The correlation between MPTP cytotoxicity and [Ca2+]i level emerging from these results, suggests that the primary effect of the molecule itself is on the plasma membrane's integrity for calcium ion regulation. © 1994.
No
Articolo in rivista - Articolo scientifico
Scientifica
3T3 MOUSE FIBROBLASTS; MPTP; ACTIN CYTOSKELETON; INTRACELLULAR CALCIUM LEVEL; ATP
English
117
126
Urani, C., Brambilla, E., Santagostino, A., & Camatini, M. (1994). 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) affects the actin cytoskeleton and calcium level of Swiss 3T3 mouse fibroblasts. TOXICOLOGY, 91(2), 117-126 [10.1016/0300-483X(94)02791-9].
Urani, C; Brambilla, E; Santagostino, A; Camatini, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/4481
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