Organization of the actin cytoskeleton, the cytosolic free-calcium concentrations and ATP levels were analyzed in 3T3 mouse fibroblasts treated with 0.75 or 1.5 mM MPTP. In the presence of the drug actin filaments were time- and dose-dependently presently disorganized, ATP level was unaffected and intracellular calcium increased within 5 s. The correlation between MPTP cytotoxicity and [Ca2+]i level emerging from these results, suggests that the primary effect of the molecule itself is on the plasma membrane's integrity for calcium ion regulation. © 1994.
Urani, C., Brambilla, E., Santagostino, A., & Camatini, M. (1994). 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) affects the actin cytoskeleton and calcium level of Swiss 3T3 mouse fibroblasts. TOXICOLOGY, 91(2), 117-126 [10.1016/0300-483X(94)02791-9].
Citazione: | Urani, C., Brambilla, E., Santagostino, A., & Camatini, M. (1994). 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) affects the actin cytoskeleton and calcium level of Swiss 3T3 mouse fibroblasts. TOXICOLOGY, 91(2), 117-126 [10.1016/0300-483X(94)02791-9]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) affects the actin cytoskeleton and calcium level of Swiss 3T3 mouse fibroblasts | |
Autori: | Urani, C; Brambilla, E; Santagostino, A; Camatini, M | |
Autori: | ||
Data di pubblicazione: | 1994 | |
Lingua: | English | |
Rivista: | TOXICOLOGY | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/0300-483X(94)02791-9 | |
Appare nelle tipologie: | 01 - Articolo su rivista |