Rat primary hepatocyte cultures have been used to study the effect of Benomyl alone or in combination with Pirimiphos-methyl. The results presented demonstrate that Benomyl alone is responsible for the microtubular disorganization in both a time- and dose-dependent manner, that the effect is reversible after the agent is removed, and that Benomyl is a potent glutathione-depleting agent. Pirimiphos-methyl, alone or combined with Benomyl had no effect on microtubule organization, but reinforced the decrease in glutathione

Urani, C., Chiesara, E., Galvani, P., Marabini, L., Santagostino, A., & Camatini, M. (1995). Benomyl affects the microtubule cytoskeleton and the glutathione level of mammalian primary cultured hepatocytes. TOXICOLOGY LETTERS, 76(2), 135-144 [10.1016/0378-4274(94)03206-M].

Benomyl affects the microtubule cytoskeleton and the glutathione level of mammalian primary cultured hepatocytes

Urani, C;Santagostino, A;Camatini, MC
1995

Abstract

Rat primary hepatocyte cultures have been used to study the effect of Benomyl alone or in combination with Pirimiphos-methyl. The results presented demonstrate that Benomyl alone is responsible for the microtubular disorganization in both a time- and dose-dependent manner, that the effect is reversible after the agent is removed, and that Benomyl is a potent glutathione-depleting agent. Pirimiphos-methyl, alone or combined with Benomyl had no effect on microtubule organization, but reinforced the decrease in glutathione
No
Articolo in rivista - Articolo scientifico
Scientifica
Primary Cultured Hepatocytes; Benomyl; Microtubules; Glutathione Level
English
135
144
10
Urani, C., Chiesara, E., Galvani, P., Marabini, L., Santagostino, A., & Camatini, M. (1995). Benomyl affects the microtubule cytoskeleton and the glutathione level of mammalian primary cultured hepatocytes. TOXICOLOGY LETTERS, 76(2), 135-144 [10.1016/0378-4274(94)03206-M].
Urani, C; Chiesara, E; Galvani, P; Marabini, L; Santagostino, A; Camatini, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/4480
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