Hypothyroidism may cause peripheral nerve damage, even if the pathophysiology of these changes is still unclear. It has been suggested by some that an increased vascular permeability is involved in hypothyroidism, while others have suggested a "compressive" mechanism caused by mucinous material deposited in the endoneurium. We have studied histologically the endoneurium and evaluated endoneural-vessel permeability in sciatic nerve by means of the leakage of horseradish peroxidase (HRP) in pharmacologically-induced hypothyroidism in rats. We did not find any substantial differences between the hypothyroid group of animals and the controls with respect to endoneural-vessel permeability. In particular, no macromolecular deposits were present in the extracellular space of the endoneurium in either the treated or the control rats. We therefore believe that a "vascular" hypothesis is unlikely for nerve involvement during hypothyroidism, nor was the "compressive" hypothesis supported by our histological findings

Cavaletti, G., Barajon, I., Petruccioli, M., & Tredici, G. (1989). Blood-nerve barrier of endoneural vessels in experimentally-induced hypothyroidism in rats. INTERNATIONAL JOURNAL OF TISSUE REACTIONS, 11(3), 137-142.

Blood-nerve barrier of endoneural vessels in experimentally-induced hypothyroidism in rats

CAVALETTI, GUIDO ANGELO;TREDICI, GIOVANNI
1989

Abstract

Hypothyroidism may cause peripheral nerve damage, even if the pathophysiology of these changes is still unclear. It has been suggested by some that an increased vascular permeability is involved in hypothyroidism, while others have suggested a "compressive" mechanism caused by mucinous material deposited in the endoneurium. We have studied histologically the endoneurium and evaluated endoneural-vessel permeability in sciatic nerve by means of the leakage of horseradish peroxidase (HRP) in pharmacologically-induced hypothyroidism in rats. We did not find any substantial differences between the hypothyroid group of animals and the controls with respect to endoneural-vessel permeability. In particular, no macromolecular deposits were present in the extracellular space of the endoneurium in either the treated or the control rats. We therefore believe that a "vascular" hypothesis is unlikely for nerve involvement during hypothyroidism, nor was the "compressive" hypothesis supported by our histological findings
No
Articolo in rivista - Articolo scientifico
Scientifica
Rats, Inbred Strains; Rats; Permeability; Animals; Methimazole; Hypothyroidism; Horseradish Peroxidase; Disease Models, Animal; Connective Tissue; Sciatic Nerve; Endothelium, Vascular
English
137
142
6
Cavaletti, G., Barajon, I., Petruccioli, M., & Tredici, G. (1989). Blood-nerve barrier of endoneural vessels in experimentally-induced hypothyroidism in rats. INTERNATIONAL JOURNAL OF TISSUE REACTIONS, 11(3), 137-142.
Cavaletti, G; Barajon, I; Petruccioli, M; Tredici, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/44791
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