Replicative senescence is an essential cellular process playing important physiological functions, but it is better known for its implications in aging, cancer, and other pathologies. One of the main triggers of replicative senescence is telomere shortening and/or its dysfunction and, therefore, a deep understanding of the molecular determinants is crucial. However, replicative senescence is a heterogeneous and hard to study process, especially in mammalian cells, and some important questions still need an answer. These questions concern i) the exact molecular causes triggering replicative senescence, ii) the role of DNA repair mechanisms and iii) the importance of R-loops at telomeres in regulating senescence onset, and iv) the mechanisms underlying the bypass of replicative senescence. In this review, we will report and discuss recent findings about these mechanisms both in mammalian cells and in the model organism Saccharomyces cerevisiae.

Pizzul, P., Rinaldi, C., Bonetti, D. (2023). The multistep path to replicative senescence onset: zooming on triggering and inhibitory events at telomeric DNA. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 11 [10.3389/fcell.2023.1250264].

The multistep path to replicative senescence onset: zooming on triggering and inhibitory events at telomeric DNA

Pizzul, Paolo
Co-primo
;
Rinaldi, Carlo
Co-primo
;
Bonetti, Diego
Ultimo
2023

Abstract

Replicative senescence is an essential cellular process playing important physiological functions, but it is better known for its implications in aging, cancer, and other pathologies. One of the main triggers of replicative senescence is telomere shortening and/or its dysfunction and, therefore, a deep understanding of the molecular determinants is crucial. However, replicative senescence is a heterogeneous and hard to study process, especially in mammalian cells, and some important questions still need an answer. These questions concern i) the exact molecular causes triggering replicative senescence, ii) the role of DNA repair mechanisms and iii) the importance of R-loops at telomeres in regulating senescence onset, and iv) the mechanisms underlying the bypass of replicative senescence. In this review, we will report and discuss recent findings about these mechanisms both in mammalian cells and in the model organism Saccharomyces cerevisiae.
Articolo in rivista - Articolo scientifico
cancer; homologous recombination; R-loops; senescence; telomere; yeast;
English
2023
11
1250264
open
Pizzul, P., Rinaldi, C., Bonetti, D. (2023). The multistep path to replicative senescence onset: zooming on triggering and inhibitory events at telomeric DNA. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 11 [10.3389/fcell.2023.1250264].
File in questo prodotto:
File Dimensione Formato  
Pizzul-2023-Front Cell Dev Biol-VoR.pdf

accesso aperto

Descrizione: Minireview
Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Licenza: Creative Commons
Dimensione 823.12 kB
Formato Adobe PDF
823.12 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/442858
Citazioni
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 2
Social impact