The evolving research landscape, with advances in the omics technologies, availability of large-scale patient cohorts, and forthcoming availability of novel drugs in primary biliary cholangitis (PBC), is creating a unique opportunity for developing a precision medicine (PM) program. PM has potential to change the paradigm of management. Diagnostic work-up of PBC patients may include information on genetic variants and molecular signature to define a particular subtype of disease and provide an estimate of treatment response and survival. To reach this point, specific interventions, such as sequencing more genomes, creating bigger biobanks, and linking biological information to health data, are needed.

Cristoferi, L., Nardi, A., Invernizzi, P., Mells, G., Carbone, M. (2020). Individualizing Care: Management Beyond Medical Therapy. SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA, 29(1), 87-103 [10.1016/j.soc.2019.08.007].

Individualizing Care: Management Beyond Medical Therapy

Invernizzi P.;Carbone M.
2020

Abstract

The evolving research landscape, with advances in the omics technologies, availability of large-scale patient cohorts, and forthcoming availability of novel drugs in primary biliary cholangitis (PBC), is creating a unique opportunity for developing a precision medicine (PM) program. PM has potential to change the paradigm of management. Diagnostic work-up of PBC patients may include information on genetic variants and molecular signature to define a particular subtype of disease and provide an estimate of treatment response and survival. To reach this point, specific interventions, such as sequencing more genomes, creating bigger biobanks, and linking biological information to health data, are needed.
Articolo in rivista - Review Essay
Autoimmune liver disease; Individualized care; Novel therapies; Omics; Precision medicine; Primary biliary cholangitis; Risk-stratification;
English
19-nov-2019
2020
29
1
87
103
none
Cristoferi, L., Nardi, A., Invernizzi, P., Mells, G., Carbone, M. (2020). Individualizing Care: Management Beyond Medical Therapy. SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA, 29(1), 87-103 [10.1016/j.soc.2019.08.007].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/442400
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