Cholangiocarcinoma remains an aggressive and deadly malignancy that is often diagnosed late. Intrinsic tumour characteristics and the growth pattern of cancer cells contribute to the challenges of diagnosis and chemoresistance. However, establishing an early and accurate diagnosis, and in some instances identifying targetable changes, has the potential to impact survival. Primary sclerosing cholangitis, a chronic cholangiopathy prodromal to the development of a minority of cholangiocarcinomas, poses a particular diagnostic challenge. We present our diagnostic and theranostic approach to the initial evaluation of cholangiocarcinomas, focusing on extrahepatic cholangiocarcinoma. This involves a multipronged strategy incorporating advanced imaging, endoscopic methods, multiple approaches to tissue sampling, and molecular markers. We also provide an algorithm for the sequential use of these tools. (c) 2023 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Cadamuro, M., Al-Taee, A., Gonda, T. (2023). Advanced endoscopy meets molecular diagnosis of cholangiocarcinoma. JOURNAL OF HEPATOLOGY, 78(5), 1063-1072 [10.1016/j.jhep.2023.01.027].

Advanced endoscopy meets molecular diagnosis of cholangiocarcinoma

Cadamuro, M;
2023

Abstract

Cholangiocarcinoma remains an aggressive and deadly malignancy that is often diagnosed late. Intrinsic tumour characteristics and the growth pattern of cancer cells contribute to the challenges of diagnosis and chemoresistance. However, establishing an early and accurate diagnosis, and in some instances identifying targetable changes, has the potential to impact survival. Primary sclerosing cholangitis, a chronic cholangiopathy prodromal to the development of a minority of cholangiocarcinomas, poses a particular diagnostic challenge. We present our diagnostic and theranostic approach to the initial evaluation of cholangiocarcinomas, focusing on extrahepatic cholangiocarcinoma. This involves a multipronged strategy incorporating advanced imaging, endoscopic methods, multiple approaches to tissue sampling, and molecular markers. We also provide an algorithm for the sequential use of these tools. (c) 2023 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Articolo in rivista - Review Essay
Bile duct strictures; Cholangiocarcinoma; Indeterminate stricture; Molecular diagnosis;
English
4-feb-2023
2023
78
5
1063
1072
none
Cadamuro, M., Al-Taee, A., Gonda, T. (2023). Advanced endoscopy meets molecular diagnosis of cholangiocarcinoma. JOURNAL OF HEPATOLOGY, 78(5), 1063-1072 [10.1016/j.jhep.2023.01.027].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/441861
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