Ellagic acid containing collagen-chitosan scaffolds as potential antioxidative bio-materials for tissue engineering applications

In this study, chitosan and collagen based scaffolds loaded with ellagic acid were synthesized with an aim to incorporate antioxidant properties within the supporting matrix. Structural characterization of the scaffolds by X-ray diffraction and Fourier transform infrared spectroscopy confirmed the presence of ellagic acid within the chitosan-collagen matrix. The 'fabricated' scaffolds exhibited sustained release of ellagic acid in phosphate buffered saline for 120 h. The scaffolds were biocompatible and supported the recovery of COS 7 cells from the oxidative stress arising due to UV irradiation. Such antioxidant incorporated scaffolds present a potential approach in managing chronic wounds by eliminating ROS.[GRAPHICS]