Background: Meeting the challenge of antiretroviral therapy (ART) whose efficacy can last a lifetime requires continuous updating of the virological, pharmacological, and quality of life outcomes to be pursued and a continuous review of literature data on the efficacy and tolerability of new drugs and therapeutic strategies. Methods: With the aim of identifying open questions and answers about the current controversies in modern ART, we adapted the Design Thinking methodology to the needs of the design phase of a scientific article, involving a team of experts in HIV care. Results: Five main pillars of treatment success were discussed: sustained virologic suppression over time; immunological recovery; pharmacological attributes; long-term tolerability and safety of ART; and people's satisfaction and quality of life. The definition of the outcomes to be achieved in each thematic area and the tools to achieve them were reviewed and discussed. Conclusions: Long-term treatment success should be intended as a combination of HIV-RNA suppression, immune recovery, and high quality of life. To achieve this, the regimen should be well-tolerated, with high potency, genetic barrier, and forgiveness, and should be tailored by a person-centered perspective, based on individual needs, preferences, and therapeutic history.

Taramasso, L., Andreoni, M., Antinori, A., Bandera, A., Bonfanti, P., Bonora, S., et al. (2023). Pillars of long-term antiretroviral therapy success. PHARMACOLOGICAL RESEARCH, 196(October 2023) [10.1016/j.phrs.2023.106898].

Pillars of long-term antiretroviral therapy success

Bonfanti, Paolo;
2023

Abstract

Background: Meeting the challenge of antiretroviral therapy (ART) whose efficacy can last a lifetime requires continuous updating of the virological, pharmacological, and quality of life outcomes to be pursued and a continuous review of literature data on the efficacy and tolerability of new drugs and therapeutic strategies. Methods: With the aim of identifying open questions and answers about the current controversies in modern ART, we adapted the Design Thinking methodology to the needs of the design phase of a scientific article, involving a team of experts in HIV care. Results: Five main pillars of treatment success were discussed: sustained virologic suppression over time; immunological recovery; pharmacological attributes; long-term tolerability and safety of ART; and people's satisfaction and quality of life. The definition of the outcomes to be achieved in each thematic area and the tools to achieve them were reviewed and discussed. Conclusions: Long-term treatment success should be intended as a combination of HIV-RNA suppression, immune recovery, and high quality of life. To achieve this, the regimen should be well-tolerated, with high potency, genetic barrier, and forgiveness, and should be tailored by a person-centered perspective, based on individual needs, preferences, and therapeutic history.
Articolo in rivista - Articolo scientifico
Antiretroviral therapy; Immunological recovery; Pharmacological attributes; Quality of life; Safety; Virologic suppression;
English
28-ago-2023
2023
196
October 2023
106898
open
Taramasso, L., Andreoni, M., Antinori, A., Bandera, A., Bonfanti, P., Bonora, S., et al. (2023). Pillars of long-term antiretroviral therapy success. PHARMACOLOGICAL RESEARCH, 196(October 2023) [10.1016/j.phrs.2023.106898].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/436460
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