Susceptibility to primary biliary cirrhosis (PBC) is strongly associated with human leukocyte antigen (HLA)-region polymorphisms. To determine if associations can be explained by classical HLA determinants, we studied Italian, 676 cases and 1440 controls, genotyped with dense single-nucleotide polymorphisms (SNPs) for which classical HLA alleles and amino acids were imputed. Although previous genome-wide association studies and our results show stronger SNP associations near DQB1, we demonstrate that the HLA signals can be attributed to classical DRB1 and DPB1 genes. Strong support for the predominant role of DRB1 is provided by our conditional analyses. We also demonstrate an independent association of DPB1. Specific HLA-DRB1 genes (*08, *11 and *14) account for most of the DRB1 association signal. Consistent with previous studies, DRB1*08 (P=1.59 × 10(-11)) was the strongest predisposing allele, whereas DRB1*11 (P=1.42 × 10(-10)) was protective. Additionally, DRB1*14 and the DPB1 association (DPB1*03:01; P=9.18 × 10(-7)) were predisposing risk alleles. No signal was observed in the HLA class 1 or class 3 regions. These findings better define the association of PBC with HLA and specifically support the role of classical HLA-DRB1 and DPB1 genes and alleles in susceptibility to PBC.

Invernizzi, P., Ransom, M., Raychaudhuri, S., Kosoy, R., Lleo, A., Shigeta, R., et al. (2012). Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis. GENES AND IMMUNITY, 13(6), 461-468 [10.1038/gene.2012.17].

Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis

INVERNIZZI, PIETRO;Bernuzzi, Francesca Veronica;STRAZZABOSCO, MARIO;
2012

Abstract

Susceptibility to primary biliary cirrhosis (PBC) is strongly associated with human leukocyte antigen (HLA)-region polymorphisms. To determine if associations can be explained by classical HLA determinants, we studied Italian, 676 cases and 1440 controls, genotyped with dense single-nucleotide polymorphisms (SNPs) for which classical HLA alleles and amino acids were imputed. Although previous genome-wide association studies and our results show stronger SNP associations near DQB1, we demonstrate that the HLA signals can be attributed to classical DRB1 and DPB1 genes. Strong support for the predominant role of DRB1 is provided by our conditional analyses. We also demonstrate an independent association of DPB1. Specific HLA-DRB1 genes (*08, *11 and *14) account for most of the DRB1 association signal. Consistent with previous studies, DRB1*08 (P=1.59 × 10(-11)) was the strongest predisposing allele, whereas DRB1*11 (P=1.42 × 10(-10)) was protective. Additionally, DRB1*14 and the DPB1 association (DPB1*03:01; P=9.18 × 10(-7)) were predisposing risk alleles. No signal was observed in the HLA class 1 or class 3 regions. These findings better define the association of PBC with HLA and specifically support the role of classical HLA-DRB1 and DPB1 genes and alleles in susceptibility to PBC.
Articolo in rivista - Articolo scientifico
antigen-binding pocket; autoimmune disease; genetic risk; imputation; risk allele; Case-Control Studies; European Continental Ancestry Group; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; HLA-DP beta-Chains; HLA-DRB1 Chains; Humans; Italy; Liver Cirrhosis, Biliary; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide; Risk Factors; Genetics (clinical); Immunology; Genetics
HLA polymorfism, PBC, HLA-DRB1, HLA-DPB1
English
461
468
8
Invernizzi, P., Ransom, M., Raychaudhuri, S., Kosoy, R., Lleo, A., Shigeta, R., et al. (2012). Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis. GENES AND IMMUNITY, 13(6), 461-468 [10.1038/gene.2012.17].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/43598
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