Emerging pharmacological strategies that target major virulence factors of antibiotic-resistant Mycobacterium tuberculosis (Mtb) are presented and discussed. This review is divided into three parts corresponding to structures and functions important for Mtb pathogenicity: the cell wall, the lipoarabinomannan, and the secretory proteins. Within the cell wall, we further focus on three biopolymeric sub-components: mycolic acids, arabinogalactan, and peptidoglycan. We present a comprehensive overview of drugs and drug candidates that target cell walls, envelopes, and secretory systems. An understanding at a molecular level of Mtb pathogenesis is provided, and potential future directions in therapeutic strategies are suggested to access new drugs to combat the growing global threat of antibiotic-resistant Mtb infection.

Italia, A., Shaik, M., Peri, F. (2023). Emerging Extracellular Molecular Targets for Innovative Pharmacological Approaches to Resistant Mtb Infection. BIOMOLECULES, 13(6) [10.3390/biom13060999].

Emerging Extracellular Molecular Targets for Innovative Pharmacological Approaches to Resistant Mtb Infection

Italia, Alice
Primo
;
Shaik, Mohammed Monsoor;Peri, Francesco
Ultimo
2023

Abstract

Emerging pharmacological strategies that target major virulence factors of antibiotic-resistant Mycobacterium tuberculosis (Mtb) are presented and discussed. This review is divided into three parts corresponding to structures and functions important for Mtb pathogenicity: the cell wall, the lipoarabinomannan, and the secretory proteins. Within the cell wall, we further focus on three biopolymeric sub-components: mycolic acids, arabinogalactan, and peptidoglycan. We present a comprehensive overview of drugs and drug candidates that target cell walls, envelopes, and secretory systems. An understanding at a molecular level of Mtb pathogenesis is provided, and potential future directions in therapeutic strategies are suggested to access new drugs to combat the growing global threat of antibiotic-resistant Mtb infection.
Articolo in rivista - Review Essay
drug development; immune system; infectious diseases; tuberculosis; virulence factors;
English
16-giu-2023
2023
13
6
999
open
Italia, A., Shaik, M., Peri, F. (2023). Emerging Extracellular Molecular Targets for Innovative Pharmacological Approaches to Resistant Mtb Infection. BIOMOLECULES, 13(6) [10.3390/biom13060999].
File in questo prodotto:
File Dimensione Formato  
Italia-2023-Biomolecules MDPI-VoR.pdf

accesso aperto

Descrizione: Review
Tipologia di allegato: Publisher’s Version (Version of Record, VoR)
Licenza: Creative Commons
Dimensione 5.38 MB
Formato Adobe PDF
5.38 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/435978
Citazioni
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
Social impact