All bound up: A small variant of protein A (red; see picture) was used as a biotemplate for the synthesis and biofunctionalization of gold nanoparticles (AuNPs). These functionalized AuNPs were able to bind to antibodies (green blocks, trastuzumab; TZ) with a defined orientation, thus showing promise as bio-nanoparticle systems suitable for selective cell labeling by membrane-receptor-specific recognition.
Colombo, M., Mazzucchelli, S., Collico, V., Avvakumova, S., Pandolfi, L., Corsi, F., et al. (2012). Protein-Assisted One-Pot Synthesis and Biofunctionalization of Spherical Gold Nanoparticles for Selective Targeting of Cancer Cells. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 51(37), 9272-9275 [10.1002/anie.201204699].
Citazione: | Colombo, M., Mazzucchelli, S., Collico, V., Avvakumova, S., Pandolfi, L., Corsi, F., et al. (2012). Protein-Assisted One-Pot Synthesis and Biofunctionalization of Spherical Gold Nanoparticles for Selective Targeting of Cancer Cells. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 51(37), 9272-9275 [10.1002/anie.201204699]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | Protein-Assisted One-Pot Synthesis and Biofunctionalization of Spherical Gold Nanoparticles for Selective Targeting of Cancer Cells | |
Autori: | Colombo, M; Mazzucchelli, S; Collico, V; Avvakumova, S; Pandolfi, L; Corsi, F; Porta, F; Prosperi, D | |
Autori: | PROSPERI, DAVIDE (Corresponding) | |
Data di pubblicazione: | 2012 | |
Lingua: | English | |
Rivista: | ANGEWANDTE CHEMIE. INTERNATIONAL EDITION | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/anie.201204699 | |
Appare nelle tipologie: | 01 - Articolo su rivista |