There is general agreement that type 2 diabetes is the consequence of insulin resistance, defined as an impaired ability of insulin to control hepatic and peripheral glucose metabolism, and of compromised pancreatic β-cell function such that insulin secretion is insufficient to compensate the degree of insulin resistance [1]. The pivotal role of insulin resistance is confirmed by the fact that it is a consistent finding in patients with type 2 diabetes. Indeed, insulin resistance may be detected 10–20 years before the onset of overt hyperglycemia and prospective studies have demonstrated that it is the best predictor of whether an individual will later become diabetic [2].
Perseghin, G. (2023). Excessive nutrients and regional energy metabolism. In L. Luzi (a cura di), Cellular Physiology and Metabolism of Physical Exercise Topical Clinical Issues Second Edition (pp. 45-56). Springer [10.1007/978-3-031-27192-2_6].
Excessive nutrients and regional energy metabolism
Perseghin, Gianluca
2023
Abstract
There is general agreement that type 2 diabetes is the consequence of insulin resistance, defined as an impaired ability of insulin to control hepatic and peripheral glucose metabolism, and of compromised pancreatic β-cell function such that insulin secretion is insufficient to compensate the degree of insulin resistance [1]. The pivotal role of insulin resistance is confirmed by the fact that it is a consistent finding in patients with type 2 diabetes. Indeed, insulin resistance may be detected 10–20 years before the onset of overt hyperglycemia and prospective studies have demonstrated that it is the best predictor of whether an individual will later become diabetic [2].
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