ϵ-caprolactone-p-coumaric acid copolymers at different mole ratios (ϵ-caprolactone:p-coumaric acid 1:0, 10:1, 8:1, 6:1, 4:1, and 2:1) were synthesized by melt-polycondensation and using 4-dodecylbenzene sulfonic acid as catalyst. Chemical analysis by NMR and GPC showed that copolyesters were formed with decreasing molecular weight as p-coumaric acid content was increased. Physical characteristics, such as thermal and mechanical properties, as well as water uptake and water permeability, depended on the mole fraction of pcoumaric acid. The p-coumarate repetitive units increased the antioxidant capacity of the copolymers, showing antibacterial activity against the common pathogen Escherichia coli. In addition, all the synthesized copolyesters, except the one with the highest concentration of the phenolic acid, were cytocompatible and hemocompatible, thus becoming potentially useful for skin regeneration applications.

Contardi, M., Alfaro-Pulido, A., Picone, P., Guzman-Puyol, S., Goldoni, L., Benitez, J., et al. (2019). Low molecular weight ϵ-caprolactone-pcoumaric acid copolymers as potential biomaterials for skin regeneration applications. PLOS ONE, 14(4) [10.1371/journal.pone.0214956].

Low molecular weight ϵ-caprolactone-pcoumaric acid copolymers as potential biomaterials for skin regeneration applications

Contardi M.;
2019

Abstract

ϵ-caprolactone-p-coumaric acid copolymers at different mole ratios (ϵ-caprolactone:p-coumaric acid 1:0, 10:1, 8:1, 6:1, 4:1, and 2:1) were synthesized by melt-polycondensation and using 4-dodecylbenzene sulfonic acid as catalyst. Chemical analysis by NMR and GPC showed that copolyesters were formed with decreasing molecular weight as p-coumaric acid content was increased. Physical characteristics, such as thermal and mechanical properties, as well as water uptake and water permeability, depended on the mole fraction of pcoumaric acid. The p-coumarate repetitive units increased the antioxidant capacity of the copolymers, showing antibacterial activity against the common pathogen Escherichia coli. In addition, all the synthesized copolyesters, except the one with the highest concentration of the phenolic acid, were cytocompatible and hemocompatible, thus becoming potentially useful for skin regeneration applications.
Articolo in rivista - Articolo scientifico
Anti-Bacterial Agents; Biocompatible Materials; Caproates; Cell Line; Escherichia coli; Humans; Lactones; Propionates; Skin; Wound Healing
English
2019
14
4
e0214956
open
Contardi, M., Alfaro-Pulido, A., Picone, P., Guzman-Puyol, S., Goldoni, L., Benitez, J., et al. (2019). Low molecular weight ϵ-caprolactone-pcoumaric acid copolymers as potential biomaterials for skin regeneration applications. PLOS ONE, 14(4) [10.1371/journal.pone.0214956].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/431918
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