Purpose: Early identification and localization of spine infection is necessary for adequate therapeutic strategy. To localize the precise site of infection we evaluated In-111 Biotin SPECT/CT versus planar and SPECT imaging. Methods: Seventy-two consecutive patients were enrolled and underwent SPECT/CT and planar imaging 2 to 4 hours post i.v. injection of In-111 Biotin. Final diagnosis was based on bacterial cultures and/or clinical/imaging follow-up for at least 1 year. We evaluated the diagnostic performance of planar, SPECT, and SPECT/CT In-111 Biotin scintigraphy. Results: In-111 Biotin SPECT/CT and SPECT showed similar values of sensitivity (93.5% vs. 92.1%) and the same specificity (92.3%), planar imaging showed 80.4% of sensitivity and 69.2% of specificity. In 16 patients SPECT/CT correctly localized the infection site (bone, soft tissue, or both bone and soft tissue). Conclusions: SPECT/CT enhances the impact of In-111 Biotin scintigraphy on the clinical management of patients, allowing the exact site of infection to be localized to select the appropriate therapy.

Lazzeri, E., Erba, P., Perri, M., Doria, R., Tascini, C., Mariani, G. (2010). Clinical impact of SPECT/CT with In-111 biotin on the management of patients with suspected spine infection. CLINICAL NUCLEAR MEDICINE, 35(1), 12-17 [10.1097/RLU.0b013e3181c36173].

Clinical impact of SPECT/CT with In-111 biotin on the management of patients with suspected spine infection

Erba, Paola;
2010

Abstract

Purpose: Early identification and localization of spine infection is necessary for adequate therapeutic strategy. To localize the precise site of infection we evaluated In-111 Biotin SPECT/CT versus planar and SPECT imaging. Methods: Seventy-two consecutive patients were enrolled and underwent SPECT/CT and planar imaging 2 to 4 hours post i.v. injection of In-111 Biotin. Final diagnosis was based on bacterial cultures and/or clinical/imaging follow-up for at least 1 year. We evaluated the diagnostic performance of planar, SPECT, and SPECT/CT In-111 Biotin scintigraphy. Results: In-111 Biotin SPECT/CT and SPECT showed similar values of sensitivity (93.5% vs. 92.1%) and the same specificity (92.3%), planar imaging showed 80.4% of sensitivity and 69.2% of specificity. In 16 patients SPECT/CT correctly localized the infection site (bone, soft tissue, or both bone and soft tissue). Conclusions: SPECT/CT enhances the impact of In-111 Biotin scintigraphy on the clinical management of patients, allowing the exact site of infection to be localized to select the appropriate therapy.
Articolo in rivista - Articolo scientifico
In-111 Biotin scintigraphy; Soft tissue infection; SPECT/CT imaging; Vertebral osteomyelitis;
English
2010
35
1
12
17
reserved
Lazzeri, E., Erba, P., Perri, M., Doria, R., Tascini, C., Mariani, G. (2010). Clinical impact of SPECT/CT with In-111 biotin on the management of patients with suspected spine infection. CLINICAL NUCLEAR MEDICINE, 35(1), 12-17 [10.1097/RLU.0b013e3181c36173].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/426486
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